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Partenariat Congés Formation Admin CBMN Conseil Institut/Scientifique
Affiliations Les sites CBMN
LIA France-Japan GEM Réseau RMN Aquitain Master AC2QMAPS IPEP master UREKA UMT FOLIES INDIA
Conseil d'Unité Animation Scientifique WEB Editorial Committee Hygiène & Sécurité Communication Administration Directoire Scientifique Direction
Chimie Biophysique Chimie Biomimétique et Thérapeuti... Biologie et Biotechnologie Administration
Christophe Bucher, Thursday July 18... Mélanie Berbon, 11 juillet 2019, 1... Hendrik W. Van Veen, July 11th, 201... Sébastien Ulrich, July 4th, 2019 ... Frédéric Brossard, 1st of July, 1... Prof. Solange Landreville, 19th of ... Prof. Hiroshi Yabu, 27th of May, 11... Amitabha Chattopadhyay, 22 May, 11 ... Prof. Hiroaki Suga, 10/05/2017, 11 ... INTERNAL CBMN SEMINAR: PHD student ... Jean Duhamel, 4 april 2019, 11am, I... Internal CBMN seminar 7 March 2019... Sandrine VIllette, 7 february 2019,... Internal CBMN Seminar : newcomers ... Internal CBMN Seminar: A. Simon, 6 ... Marisela Velez, 28 november 2018, 2... Marc Bramkamp, 16 november 2018, 2p... Kazushi Kinbara, 12 november 2018, ... Internal CBMN Seminar: J. Lang, 8 N... Internal CBMN Seminars: A. Baudin, ... Plateforme production de protéine... Patrick Trouillas, 21 June 2018, 2p... Lucie Khemtemourian, 21 June 2018, ... Jonathan Faherty, 7th June, 11 AM, ... Yann Fichou, 3 May 2018, 2pm, IECB Internal CBMN seminars: A. Ciaccafa... Alain Roussel, 29/03/2018, 4 pm, EN... Simon Poly, 22 march 2018, 2pm, ENS... J.Crassous, M. Sallé & A. Martinez... O.Reinaud & V. Artero, 7/12/2017, 1... R. Dos santos Morais, 30/11/2017, 4... Christian Griesinger, November 24th... Takahiro Muraoka, 16/11/2017, 11am,... Vladimir Torbeev, 9/11/2017, 2pm, E... M. D. Smith & T.Constantieux, 3/11/... James Nowick, 15 september 2017, 11... Emmanuelle Thinon, 28 June 2017, 11... Caroline Tokarski, 15 June 2017, 4p... Christian Salesse, 8 June 2017, 4pm... Patrice Rey, 01 June 2017, 2h30 pm,... Christina Sizun, 18 May 2017, 4 pm,... Marisela Velez, 5 May 2017, 11am, I... Iqbal Choudhary, 27 April 2017, 4 p... Vincent Aucagne, 21 April 2017, 11 ... Sophie Zinn-Justin, 14 April 2017, ... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
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Patricia DULOR Anthony BOUTER Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Yann FERRAND Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Caroline TOKARSKI

Séminaire du professeur Hiroko Isoda, le 24 novembre 2016, 11h à l'IECB



Dans le cadre du master international: Analytical chemistry for drugs and natural products labilisé IDEX à la faculté de pharmacie de Bordeaux. Le Pr Hiroko Isoda de l’université de Tsukuba au Japon, fera une présentation de ses thématiques de recherche phares le jeudi 24/11 à 11h00 à l’amphithéâtre de l’IECB, 2 rue Robert Escarpit, Pessac

 

Le professeur Hiroko Isoda dirige le « School of Integrative and Global Majors (SIGMA)” qui regroupe des chercheurs et étudiants autour de la thématique de la Fonctionnalité des aliments et des produits naturels et du Drug Discovery en particulier dans l'induction de la différenciation Cellulaire : Neuronales cancéreuses et des cellules souches.

 

Ses travaux de recherches s’intéressent plus particulièrement à la valorisation des bio-ressources dans la région méditerranéenne.

 

 

Roles of Anti-Oxidant Molecules on Natural Compounds Drug Discovery

 

Hiroko ISODA, Professor

Faculty of Life and Environment/Alliance for Research on North Africa,University of Tsukuba

 

Abstract

 

 

Caffeoylquinic acid (CQA) derivatives are polyphenolic compounds found in wide variety of plants. Previously, we have demonstrated that di- CQA and tri- CQA had neuroprotective effect through their ability to promote intracellular adenosine-5’- triphosphate (ATP) generation and by up-regulation of glycolytic enzyme expression. In the present study we have investigated the effect of di- CQA and tri- CQA on energy metabolism in SH-SY5Y cells using a metabolomics approach. Results indicate that di- CQA treatment of SH-SY5Ycells significantly increases the production of an array of glycolysis metabolites and tricarboxylic acid (TCA) cycle metabolites, including acetyl-CoA, succinic acid, fumaric acid, and malic acid. Tri-CQA treatment was also observed to increase the levels of all glycolysis and TCA cycle metabolites and evoked a stronger effect than that of di-CQA. In addition to their effects on glycolytic metabolites, di-CQA and tri-CQA exposure also induced a significant increase in the production of ATP, ADP, GTP, and GDP. Our results suggest that CQA-induction of intracellular ATP synthesis is mediated by the activation of central metabolic pathways including the activation of glycolysis and the TCA cycle. Based on those data, we performed Morris water maze test on CQAs fed SAMP-8 aging model mice and proteomics analysis of brains. CQAs improved spatial learning memory of SAMP-8 mice and enhance the biomarker expression of neurogenesis, neuroplasticity and energy metabolism in those mice brain (Neuroscience 2010, 169,1039-45).

 

The erythroid differentiation-inducing effect of apigenin and its derivatives on human chronic myeloid leukemia K562 has been reported but the functional group in its structure responsible for the effect has not yet been elucidated. Here, we determined the moiety responsible for the erythroid differentiation induction effect of apigenin by using different flavonoids to represent the functional groups in its structure. In addition, we compared apigenin and apigetrin, a flavonoid similar in structure to apigenin except for the glycoside in its structure. Morphological changes as well as expressions of specific markers in K562 cells treated with apigenin were compared with those treated with apigetrin, flavone, 7-hydroxyflavone, chrysin, luteolin, or naringenin. The anti-proliferative and erythroid differentiation-inducing effect of apigenin and the five flavonoids were then investigated and their effects on the α, β, and γ globin genes expressions were compared using real-time PCR. Results of the comparison between apigenin and apigetrin revealed that the glycoside part of apigetrin does not have a role in the induction of cell differentiation. Based on glycophorin A expression, the potency of the other flavonoids for induction of differentiation, was: apigenin > chrysin > flavone/7-hydroxyflavone > luteolin/naringenin. Results of the analysis of the relationship between the structure and function of the flavonoids suggest that the apigenin-induced K562 cell differentiation was due to the 2–3 double bond and hydroxyl groups in its structure. This is the first study that identified the specific functional group in apigenin that impact the erythroid differentiation effect in K562 cells (Mol Nutr Food Res. 2011, 55, 93-102, See comment in PubMed Commons belowChem Biol Interact.2014, 220, 269-277).

 

 

Courte Biographie

 

Faculté des sciences de la vie et de l’environnement
School of Integrative and Global Majors (SIGMA)/
Alliance for Research on North Africa (ARENA)  
University of Tsukuba


Publications récentes:


Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. Imen Samet; Myra O. Villareal; Hideko Motojima; Junkyu Han; Sami Sayadi; Hiroko Isoda. Differentiation Vol. 89, 146-155, 2015.


Cyanidin-3-glucoside derived from black soybeans ameliorate type 2 diabetes through the induction of differentiation of preadipocytes into smaller and insulin-sensitive adipocytes. Toshiya Matsukawa; Tetsuya Inaguma; Junkyu Han; Myra O. Villareal; Hiroko Isoda, Journal of Nutritional Biochemistry, Vol. 26, 860-867, 2015.


Antidepressant-like effects of rosmarinic acid through mitogen-activated protein kinase phosphatase-1 and brain-derived neurotrophic factor modulationShinji Kondo; Abdelfatteh El Omri; Junkyu Han; Isoda Hiroko, Journal of Functional Foods, Vol. 14, 758-766, 2015.

 

Contact: Boutayna Frih, boutayna.frih@u-bordeaux.fr

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