Institut de Chimie & Biologie des Membranes & des Nano-objets • Bordeaux

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Iqbal Choudhary, 27 April 2017, 4 p... Marisela Velez, 5 May 2017, 11am, I... Christina Sizun, 18 May 2017, 4 pm,... Christian Salesse, 8 June 2017, 4pm... Vincent Aucagne, 21 April 2017, 11 ... Sophie Zinn-Justin, 14 April 2017, ... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
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Patricia DULOR Alain BRISSON Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Ivan HUC Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

Banafshe Larijani, 12 March 2015, 16h, ENSCBP

The seminar will take place at 16h00, the 12th of March 2015, in the ENSCBP Amphitheater (Bldg B, Allée Geoffroy Saint Hilaire, Pessac)

 

Title: Effects of phosphoinositides and their derivatives on membrane morphology and function.

 

PROF. BANAFSHE LARIJANI

(Cell Biophysics Laboratory, Ikerbasque Research Professor)

 

ABSTRACT

 

To suggest and develop intelligent strategies to comprehend the regulation of organelle formation, a deeper mechanistic interpretation requires more than just the involvement of proteins. Our approaches link the formation of endo-membranes with both signalling and membrane physical properties.

 

Our studies derive from a cross-disciplinary approach undertaken to determine the molecular mechanisms of nuclear envelope assembly in echinoderm and mammalian cells. Our findings have led to the demonstration of a direct role for phosphoinositides and their derivatives in nuclear membrane formation. We have shown that phosphoinositides and their derivatives, as well as acting as second messengers, are modulators of membrane morphology, and their modifying enzymes regulate nuclear envelope formation. We aim to demonstrate that proteins do not solely drive morphology and dynamics (fusion) of subcellular compartments, which should be instead be considered proteo-lipid events.

 

Short Biography

Banafshé Larijani is Head of Cell Biophysics laboratory since 2002 at Cancer Research UK, was appointed Senior Scientist in 2013 and in 2014 was awarded an Ikerbasque Research Professorship where she moved her laboratory to the Biophysics Institute- Bilbao, Spain. She holds an adjunct professorship with Stony Brooks University NY and University of Massachusetts, Amherst MA. Banafshé’s laboratory is a cutting edge cross-disciplinary platform, which draws upon the physical sciences to develop novel avenues for investigation of biological processes. Her laboratory has led to paving a unique path by investigating the role of phosphoinositides and their metabolites, both as second messengers and as modulators of membrane morphology.  The outcomes of her fundamental research involving the application of quantitative imaging (FRET-FLIM) for investigating molecular mechanisms of phosphoinositide-modifying and phosphoinositide-dependant enzymes have resulted in their application to various clinical objectives

 

 

Contacts: jm.schmitter@cbmn.u-bordeaux.fr & e.dufourc@cbmn.u-bordeaux.fr

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