The seminar will take place at 16h00, the 12th of March 2015, in the ENSCBP Amphitheater (Bldg B, Allée Geoffroy Saint Hilaire, Pessac)
To suggest and develop intelligent strategies to comprehend the regulation of organelle formation, a deeper mechanistic interpretation requires more than just the involvement of proteins. Our approaches link the formation of endo-membranes with both signalling and membrane physical properties.
Our studies derive from a cross-disciplinary approach undertaken to determine the molecular mechanisms of nuclear envelope assembly in echinoderm and mammalian cells. Our findings have led to the demonstration of a direct role for phosphoinositides and their derivatives in nuclear membrane formation. We have shown that phosphoinositides and their derivatives, as well as acting as second messengers, are modulators of membrane morphology, and their modifying enzymes regulate nuclear envelope formation. We aim to demonstrate that proteins do not solely drive morphology and dynamics (fusion) of subcellular compartments, which should be instead be considered proteo-lipid events.
|Banafshé Larijani is Head of Cell Biophysics laboratory since 2002 at Cancer Research UK, was appointed Senior Scientist in 2013 and in 2014 was awarded an Ikerbasque Research Professorship where she moved her laboratory to the Biophysics Institute- Bilbao, Spain. She holds an adjunct professorship with Stony Brooks University NY and University of Massachusetts, Amherst MA. Banafshé’s laboratory is a cutting edge cross-disciplinary platform, which draws upon the physical sciences to develop novel avenues for investigation of biological processes. Her laboratory has led to paving a unique path by investigating the role of phosphoinositides and their metabolites, both as second messengers and as modulators of membrane morphology. The outcomes of her fundamental research involving the application of quantitative imaging (FRET-FLIM) for investigating molecular mechanisms of phosphoinositide-modifying and phosphoinositide-dependant enzymes have resulted in their application to various clinical objectives|