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Patricia DULOR Alain BRISSON Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Ivan HUC Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

Pascale Schellenberger, 21 Mai 2015, 16h

The seminar will take place at 16h00, the 21th of May 2015, in the ENSCBP Amphitheater (Bldg B, Allée Geoffroy Saint Hilaire, Pessac)

 

Structure of the Caveolar coat studied in vitro and in-situ by cryo electron tomography

 

Dr. Pascale Schellenberger

Oxford Particle Imaging Centre
The Division of Structural Biology
The Wellcome Trust Centre for Human Genetics
University of Oxford

 

ABSTRACT

 

Caveolae are highly abundant membrane micro-domains forming invaginations at the plasma membrane of many mammalian cells. They are involved in various cellular processes including endocytosis, cell motility, lipid homeostasis, signalling, pathogen entry and cancer. Structural information about the caveolar architecture has remained enigmatic. The three major structural coat proteins include the integral membrane protein caveolin, and the peripherally attached cavin and EHD2 proteins. They form large, independently assembled complexes on the cytosolic face of caveolae.

 

The objective of our study is to identify structural domains of the cavin complex and residues within the protein that confer specificity of binding to lipids and cavin assembly into a large native complex. We purified cavin coat complexes from mammalian cells and analyzed their structure in solution and after reconstitution into liposomes. In parallel, caveolae were imaged in situ in vitrified cells by cryo electron tomography. Our results lead to a new model of caveolar coat assembly and reveal insights on how caveolae induce membrane curvature.

 

Short biography

 

Pascale Schellenberger did her PhD at The University of Strasbourg under the supervision of Dr. Christophe Ritzenthaler (IBMP, Strasbourg) and Dr. Oliver Lemaire (INRA, Colmar) working on Plant virology with an emphasis on structural biology. In 2010, she joined Pr. Kay Grünewald’s group at the University of Oxford to develop correlative light and electron tomography on frozen hydrated samples at high resolution. She is currently interested in membrane remodelling with a focus on the Caveolar coat structures and Adenovirus entry mechanism.

 

Contact @ CBMN: o.lambert@cbmn.u-bordeaux.fr

 

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Dernière mise à jour : 24/02/2017

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