Institute of Chemistry & Biology of Membranes & Nano-objects • Bordeaux

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Jean Duhamel, 4 april 2019, 11am, I... Internal CBMN seminar 7 March 2019... Sandrine VIllette, 7 february 2019,... Internal CBMN Seminar : newcomers ... Internal CBMN Seminar: A. Simon, 6 ... Marisela Velez, 28 november 2018, 2... Marc Bramkamp, 16 november 2018, 2p... Kazushi Kinbara, 12 november 2018, ... Internal CBMN Seminar: J. Lang, 8 N... Internal CBMN Seminars: A. Baudin, ... Plateforme production de protéine... Patrick Trouillas, 21 June 2018, 2p... Lucie Khemtemourian, 21 June 2018, ... Jonathan Faherty, 7th June, 11 AM, ... Yann Fichou, 3 May 2018, 2pm, IECB Internal CBMN seminars: A. Ciaccafa... Alain Roussel, 29/03/2018, 4 pm, EN... Simon Poly, 22 march 2018, 2pm, ENS... J.Crassous, M. Sallé & A. Martinez... O.Reinaud & V. Artero, 7/12/2017, 1... R. Dos santos Morais, 30/11/2017, 4... Christian Griesinger, November 24th... Takahiro Muraoka, 16/11/2017, 11am,... Vladimir Torbeev, 9/11/2017, 2pm, E... M. D. Smith & T.Constantieux, 3/11/... James Nowick, 15 september 2017, 11... Emmanuelle Thinon, 28 June 2017, 11... Caroline Tokarski, 15 June 2017, 4p... Christian Salesse, 8 June 2017, 4pm... Patrice Rey, 01 June 2017, 2h30 pm,... Christina Sizun, 18 May 2017, 4 pm,... Marisela Velez, 5 May 2017, 11am, I... Iqbal Choudhary, 27 April 2017, 4 p... Vincent Aucagne, 21 April 2017, 11 ... Sophie Zinn-Justin, 14 April 2017, ... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
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Patricia DULOR Anthony BOUTER Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Yann FERRAND Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

Ahmad Saad's thesis defense, Wednesday 20 December 2017, 2 pm



The thesis defense will take place, Wednesday 20 December 2017, at 2 pm, at the IECB, 2 rue Robert Escarpit, Pessac.

 

Wine tannins and lipids of the mouth and foods: towards a modification of the markers of taste. A molecular and sensory approach.

 

Abstract

 

Tannins are polyphenol polymers present in significant amounts in red wine responsible for astringency and bitterness. The former is a tactile perception involving dryness and roughness in the mouth due to the interaction between tannins and saliva proteins and the latter is a primary taste due to the interaction between tannins and taste receptors in taste buds. Tannins are now known to also interact with lipids. Although not present in wine, lipids are yet present during tasting in the oral membranes of tasters and in fatty foods when wine is consumed during a meal. However, although the influence of lipids is well known to wine tasters through food pairing, there is no scientific evidence to support this hedonic feeling.

 

The aim of the thesis is to study tannin-lipid interactions at molecular level in order to better understand their implication in wine gustative properties. The present work describes the effect of the main representative grape tannin subunits, the catechin monomer and the B1 dimer, both on a model of oral membranes and food fat globules. They are represented by a dispersion of POPC/cholesterol multilamellar vesicles and an olive oil in water emulsion stabilized by DMPC as emulsifier, respectively. The organization and dynamics of the lipids composing these two models were investigated by solid-state NMR spectroscopy (1H, 2H, and 13C) in the absence and the presence of the two tannin subunits. The affinity of tannins for lipids was also explored by the determination of the thermodynamic association constant.

 

The results pointed out a fluidizing effect of tannins both on the membrane model, and on the emulsion lipid droplets. The disorder caused by tannins was shown to be related to their location in the lipid structure depending on the tannin chemical nature. Moreover, the strength of the interaction between tannins and membrane lipids was revealed to be in the same order of magnitude of that between tannins and saliva. In addition, the biophysical results were in accordance with those of a sensory analysis led in parallel that revealed that fatty foods are prone to decrease wine astringency.

 

These pioneering works shows the impact of phenolic compounds on the membrane order and highlight for the first time the potential role of the tannin-lipid interactions on wine taste. On the one hand, by disrupting the lipid environment of taste receptors embedded in oral membranes, tannin-lipid interactions could affect the receptor functionality and therefore the interaction with tannin molecules, so bitterness. On the other hand, the existence of a possible competition between lipids and saliva proteins for interacting with tannins during tasting could reduce astringency. In the domain of oenology this thesis open a new perspectives in the context of food and wine pairing.

 

Keywords: ssNMR, tannins, membrane dynamics, emulsion, affinity, wine taste.

Supervision: Dr. Julie Géan, Dr. Erick Dufourc.

Team: NMR of Membranes and Protein Assemblies

 

 

 

 

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