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Patricia DULOR Alain BRISSON Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Ivan HUC Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

Christophe Cullin, 10 september 2015, 14 h

The seminar will take place at 14h00, the 10th of September 2015, in the ENSCBP Amphitheater (Bldg B, Allée Geoffroy Saint Hilaire, Pessac).

 

Modeling toxic and invasive properties of two amyloids involved in Alzheimer Disease: from yeast to in vitro analysis

 

Professor Christophe Cullin

IBGC

 

ABSTRACT

 

Several dozen of amyloid proteins are able to auto associate into highly organized fibrillar structures. This organization, based on cross-beta association, gives amyloid different properties. For instance, the mechanical properties of amyloid fibrils found in spider silk is used to form spider’s web.

 

Obviously, most of the studies on amyloid are related to two other biological properties: toxicity and propagation. With the help of a yeast system, we have combined genetic and biochemical approaches and have found that prion properties of one amyloid protein was lost in mutants that are more prone to aggregate in vitro.

 

More recently, we have focused on two amyloid involved in Alzheimer disease (AD). The amyloid cascade paradigm emphasized the essential role of Aß in AD. It is widely admitted that Aß aggregation triggers the pathological events leading to neuronal death. These mechanisms involve also the hyper-phosphorylation and amyloid aggregation of another partner: Tau.

 

In a frame of a collaboration with S. Lecomte (CBMN, Bordeaux), we combined different approaches and put in place a structure-toxicity study of Aß. Another collaboration with J. Winderickx (KUL, Leuven) allowed us to develop a model in which Aß and Tau exhibit a synergistic toxicity. I will present part of these results and will discuss the future of this work.

 

 

Short biography

 

Christophe Cullin was born on August 15, 1962 in Versailles, France. He obtained his PhD in 1991 at the University Paris 6. He get a post-doc position in F. Lacroute’s laboratory (CGM, Gif-sur-Yvette) and developed many different approaches centred on the functional analysis of S. cerevisiae genome. He became assistant-professor in 1994 and turned his interest on [URE3], a yeast prion. In 1997, he became group leader and created a team (Structural Heredity and Prion) interested in yeast prion biology. In September 2000, he moved to Bordeaux and was appointed as full professor at the University of Bordeaux Ségalen. He created a new team at IBGC involved in amyloid study. He is a member of several scientific organizations, member of the editorial board of "Microbial Cell" and "Prion" and author of more than 50 publications.

 

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