Institute of Chemistry & Biology of Membranes & Nano-objects • Bordeaux

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Prof. Hiroshi Yabu, 27th of May, 11 am, IECB Amitabha Chattopadhyay, 22 May, 11 am, IECB Prof. Hiroaki Suga, 10/05/2017, 11 am, IECB INTERNAL CBMN SEMINAR: PHD student and post-doc seminar, 2nd of may, 2pm Jean Duhamel, 4 april 2019, 11am, IECB Internal CBMN seminar 7 March 2019: « my thesis in 180 seconds » + new PhD students presentation Sandrine VIllette, 7 february 2019, 2pm, ENSCBP(B) Internal CBMN Seminar : newcomers in CBMN, 17th of January, 2pm Internal CBMN Seminar: A. Simon, 6 Dec. 2018 Marisela Velez, 28 november 2018, 2pm, IECB Marc Bramkamp, 16 november 2018, 2pm, IECB Kazushi Kinbara, 12 november 2018, 11am, IECB Internal CBMN Seminar: J. Lang, 8 November 2018 Internal CBMN Seminars: A. Baudin, 6 September 2018 Plateforme production de protéines, 5 juillet 2018, 14h, ENSTBB Patrick Trouillas, 21 June 2018, 2pm, ENSCBP Lucie Khemtemourian, 21 June 2018, 11am, IECB Jonathan Faherty, 7th June, 11 AM, IECB Yann Fichou, 3 May 2018, 2pm, IECB Internal CBMN seminars: A. Ciaccafava and G. Compain, 5 April 2018 Alain Roussel, 29/03/2018, 4 pm, ENSCBP Simon Poly, 22 march 2018, 2pm, ENSCBP J.Crassous, M. Sallé & A. Martinez, 18/12/2017, 10 am, IECB O.Reinaud & V. Artero, 7/12/2017, 10 am, IECB R. Dos santos Morais, 30/11/2017, 4 PM, ENSCBP Christian Griesinger, November 24th, 11am, IECB Takahiro Muraoka, 16/11/2017, 11am, ENSCBP Vladimir Torbeev, 9/11/2017, 2pm, ENSCBP M. D. Smith & T.Constantieux, 3/11/2017, 2h30 pm, IECB James Nowick, 15 september 2017, 11am, IECB Emmanuelle Thinon, 28 June 2017, 11 am, IECB Caroline Tokarski, 15 June 2017, 4pm, ENSCBP Christian Salesse, 8 June 2017, 4pm, ENSCBP Patrice Rey, 01 June 2017, 2h30 pm, ENSCBP Christina Sizun, 18 May 2017, 4 pm, ENSCBP Marisela Velez, 5 May 2017, 11am, IECB Iqbal Choudhary, 27 April 2017, 4 pm, ENSCBP Vincent Aucagne, 21 April 2017, 11 am, IECB Sophie Zinn-Justin, 14 April 2017, 11 am, IECB Cécile Feuillie, 16 February 2017, 4 PM, ENSCBP Félix M. Goñi, 8 december 2016, 4 pm, ENSCBP Félix M. Goñi, 17 november 2016, 4 pm, ENSCBP Carl Creutz, 20 october 2016, 4 pm, ENSCBP Diego Romero, 30 september 2016, 11 am, IECB A. Ciaccafava, 8 september 2016, 14h, ENSCBP A. Ramamoorthy, 16 June 2016, 16h, ENSCBP Alexandre de Brevern, 2 june 2016, ENSCBP Isabelle Landrieu, 26 May, 16h, ENSCBP Frances Sepavoric, 12 May, 16h, ENSCBP Thomas Pradeu, 7 April 2016, 9h, ENSCBP Françoise Argoul, 3 march 2016, 16h, ENSCBP Corinne Loutelier-Bourhis, 16/12/2015, 16h Aristotelis XENAKIS, 3 december 2015, 16h Fabian Kiessling, 26 november 2015, 11h Michaël Molinari, 20 november 2015, 11h Dipankar Das Sarma, 28 October 2015, 14h. Olivier Donard, 22 october 2015, 16h, ENSCBP E. Morvan & A.Grelard, 17/12/2015, 16h, ENSCBP Christophe Cullin, 10 september 2015, 14 h Brigitte Lindet, 18 June 2015, 16h, ENSCBP(B) Marion Decossas, 4 June 2015, 16h, ENSCBP(B) Pascale Schellenberger, 21 Mai 2015, 16h F. Leal-Calderon, 7 May 2015, 16h, ENSCBP(B) Ibrahim Abdulhalim, 9 April 2015, 14h, ENSCBP Manon Carré, 26 March 2015, 14h, ENSCBP(B) C. Bure & JM Schmitter, 19 March 2015, 16h T. Ogata & H. Ihara, 17 March 2015, 11h, IECB Banafshe Larijani, 12 March 2015, 16h, ENSCBP
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Prof. Hiroshi Yabu, 27th of May, 11... Amitabha Chattopadhyay, 22 May, 11 ... Prof. Hiroaki Suga, 10/05/2017, 11 ... INTERNAL CBMN SEMINAR: PHD student ... Jean Duhamel, 4 april 2019, 11am, I... Internal CBMN seminar 7 March 2019... Sandrine VIllette, 7 february 2019,... Internal CBMN Seminar : newcomers ... Internal CBMN Seminar: A. Simon, 6 ... Marisela Velez, 28 november 2018, 2... Marc Bramkamp, 16 november 2018, 2p... Kazushi Kinbara, 12 november 2018, ... Internal CBMN Seminar: J. Lang, 8 N... Internal CBMN Seminars: A. Baudin, ... Plateforme production de protéine... Patrick Trouillas, 21 June 2018, 2p... Lucie Khemtemourian, 21 June 2018, ... Jonathan Faherty, 7th June, 11 AM, ... Yann Fichou, 3 May 2018, 2pm, IECB Internal CBMN seminars: A. Ciaccafa... Alain Roussel, 29/03/2018, 4 pm, EN... Simon Poly, 22 march 2018, 2pm, ENS... J.Crassous, M. Sallé & A. Martinez... O.Reinaud & V. Artero, 7/12/2017, 1... R. Dos santos Morais, 30/11/2017, 4... Christian Griesinger, November 24th... Takahiro Muraoka, 16/11/2017, 11am,... Vladimir Torbeev, 9/11/2017, 2pm, E... M. D. Smith & T.Constantieux, 3/11/... James Nowick, 15 september 2017, 11... Emmanuelle Thinon, 28 June 2017, 11... Caroline Tokarski, 15 June 2017, 4p... Christian Salesse, 8 June 2017, 4pm... Patrice Rey, 01 June 2017, 2h30 pm,... Christina Sizun, 18 May 2017, 4 pm,... Marisela Velez, 5 May 2017, 11am, I... Iqbal Choudhary, 27 April 2017, 4 p... Vincent Aucagne, 21 April 2017, 11 ... Sophie Zinn-Justin, 14 April 2017, ... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
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Patricia DULOR Anthony BOUTER Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Yann FERRAND Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

Christine Bourgeois thesis defense, Monday December 10th 2018 at 3:30 p.m. (French hour), FSAA Council Chamber (1110-1116), Paul Comtois Pavilion, University Laval, Quebec Visioconference in room visio A – ENSCBP bat A (16 avenue Pey Berland in Pessac)



The defense will take place, Monday December 10th 2018 at 3:30 p.m. (French hour), FSAA Council Chamber (1110-1116), Paul Comtois Pavilion, University Laval, Quebec Visioconference in room visio A – ENSCBP bat A (16 avenue Pey Berland in Pessac).

 

Influence of colloidal interface structuration on formulation and nutritional fatty acid bioavailability

 

Abstract

 

Recent epidemiologic studies show an insufficient intake of polyunsaturated fatty acids (PUFA) in occidental countries. Besides, the sensibility of PUFA to oxidation is one of the major causes of organoleptic and nutritional quality deterioration in food products. Moreover, lipids in food products are often in an emulsified stage. Therefore, industrials that care to formulate PUFA enriched food products adopt technological strategies to protect and stabilize the lipids while improving their bioavailability. One of those strategies consists in looking for stable emulsified systems that already exist in nature, extract tensioactive molecules of interest and mimic the lipid state. In this context, several studies deal with oil bodies (OB), that are natural occurring structures for lipid storage in oleaginous plants, composed of proteins (OBP) and phospholipids (PL).

 

Therefore, the main objective of this PhD work is to manage emulsion formulation only based on canola (oil, PL and OBP). This goes through: 1) an understanding of the interactions between PL and OBP; 2) a study of the stability of the emulsions under storage and gastrointestinal conditions, and finally, 3) an investigation of the influence of the emulsion interfacial composition on the bioavailability of PUFA in rats.

 

The spectroscopic studies of the model PL:OBP interactions showed favorable interactions for stabilizing the emulsions based on anionic PL, unsaturated PL and OBP. These results allowed choosing an adequate canola lecithin. The PL:OBP interactions, modulated by the pH and the PL:OB ratio, influences the formation of the emulsions, the quantity of OBP adsorbed at the interface and the physical stability of emulsions with a pronounced creaming in emulsions rich in proteins. The PL:OBP synergy at the interface seems to be a decisive factor to slow down the oxidation of the emulsified canola oil. The emulsion behavior in conditions that mimic that of the gastrointestinal track, shows that the presence of OBP at the interface favored the emulsion flocculation at acid pH (mimicking that of the stomach). However, the flocculation was reversible when the pH was adjusted to a value close to that of theintestine. OBP also increased the activity of the pancreatic lipase in vitro. Finally, the presence of PL and OBP at the interface increased the lymphatic bioaccessibility of the PUFA in rats.

 

On the whole, we showed that it is possible to manage emulsion formulation only based on canola products. This could be of peculiar interest for clean labeling or vegan nutrition by subtracting synthetic emulsifiers or emulsifiers from animal origin, respectively.

 

Keywords : Emulsions, bioaccessibility, oxidation, canola/rapeseed, interactions phospholipids-proteins

 

Supervision : Pr. Maud CANSELL & Pr. Muriel SUBIRADE

 

 

 

 

 

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