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Internal CBMN Seminar : newcomers in CBMN, 17th of January, 2pm Internal CBMN Seminar: A. Simon, 6 Dec. 2018 Marisela Velez, 28 november 2018, 2pm, IECB Marc Bramkamp, 16 november 2018, 2pm, IECB Kazushi Kinbara, 12 november 2018, 11am, IECB Internal CBMN Seminar: J. Lang, 8 November 2018 Internal CBMN Seminars: A. Baudin, 6 September 2018 Plateforme production de protéines, 5 juillet 2018, 14h, ENSTBB Patrick Trouillas, 21 June 2018, 2pm, ENSCBP Lucie Khemtemourian, 21 June 2018, 11am, IECB Jonathan Faherty, 7th June, 11 AM, IECB Yann Fichou, 3 May 2018, 2pm, IECB Internal CBMN seminars: A. Ciaccafava and G. Compain, 5 April 2018 Alain Roussel, 29/03/2018, 4 pm, ENSCBP Simon Poly, 22 march 2018, 2pm, ENSCBP J.Crassous, M. Sallé & A. Martinez, 18/12/2017, 10 am, IECB O.Reinaud & V. Artero, 7/12/2017, 10 am, IECB R. Dos santos Morais, 30/11/2017, 4 PM, ENSCBP Christian Griesinger, November 24th, 11am, IECB Takahiro Muraoka, 16/11/2017, 11am, ENSCBP Vladimir Torbeev, 9/11/2017, 2pm, ENSCBP M. D. Smith & T.Constantieux, 3/11/2017, 2h30 pm, IECB James Nowick, 15 september 2017, 11am, IECB Emmanuelle Thinon, 28 June 2017, 11 am, IECB Caroline Tokarski, 15 June 2017, 4pm, ENSCBP Christian Salesse, 8 June 2017, 4pm, ENSCBP Patrice Rey, 01 June 2017, 2h30 pm, ENSCBP Christina Sizun, 18 May 2017, 4 pm, ENSCBP Marisela Velez, 5 May 2017, 11am, IECB Iqbal Choudhary, 27 April 2017, 4 pm, ENSCBP Vincent Aucagne, 21 April 2017, 11 am, IECB Sophie Zinn-Justin, 14 April 2017, 11 am, IECB Cécile Feuillie, 16 February 2017, 4 PM, ENSCBP Félix M. Goñi, 8 december 2016, 4 pm, ENSCBP Félix M. Goñi, 17 november 2016, 4 pm, ENSCBP Carl Creutz, 20 october 2016, 4 pm, ENSCBP Diego Romero, 30 september 2016, 11 am, IECB A. Ciaccafava, 8 september 2016, 14h, ENSCBP A. Ramamoorthy, 16 June 2016, 16h, ENSCBP Alexandre de Brevern, 2 june 2016, ENSCBP Isabelle Landrieu, 26 May, 16h, ENSCBP Frances Sepavoric, 12 May, 16h, ENSCBP Thomas Pradeu, 7 April 2016, 9h, ENSCBP Françoise Argoul, 3 march 2016, 16h, ENSCBP Corinne Loutelier-Bourhis, 16/12/2015, 16h Aristotelis XENAKIS, 3 december 2015, 16h Fabian Kiessling, 26 november 2015, 11h Michaël Molinari, 20 november 2015, 11h Dipankar Das Sarma, 28 October 2015, 14h. Olivier Donard, 22 october 2015, 16h, ENSCBP E. Morvan & A.Grelard, 17/12/2015, 16h, ENSCBP Christophe Cullin, 10 september 2015, 14 h Brigitte Lindet, 18 June 2015, 16h, ENSCBP(B) Marion Decossas, 4 June 2015, 16h, ENSCBP(B) Pascale Schellenberger, 21 Mai 2015, 16h F. Leal-Calderon, 7 May 2015, 16h, ENSCBP(B) Ibrahim Abdulhalim, 9 April 2015, 14h, ENSCBP Manon Carré, 26 March 2015, 14h, ENSCBP(B) C. Bure & JM Schmitter, 19 March 2015, 16h T. Ogata & H. Ihara, 17 March 2015, 11h, IECB Banafshe Larijani, 12 March 2015, 16h, ENSCBP
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Internal CBMN Seminar : newcomers ... Internal CBMN Seminar: A. Simon, 6 ... Marisela Velez, 28 november 2018, 2... Marc Bramkamp, 16 november 2018, 2p... Kazushi Kinbara, 12 november 2018, ... Internal CBMN Seminar: J. Lang, 8 N... Internal CBMN Seminars: A. Baudin, ... Plateforme production de protéine... Patrick Trouillas, 21 June 2018, 2p... Lucie Khemtemourian, 21 June 2018, ... Jonathan Faherty, 7th June, 11 AM, ... Yann Fichou, 3 May 2018, 2pm, IECB Internal CBMN seminars: A. Ciaccafa... Alain Roussel, 29/03/2018, 4 pm, EN... Simon Poly, 22 march 2018, 2pm, ENS... J.Crassous, M. Sallé & A. Martinez... O.Reinaud & V. Artero, 7/12/2017, 1... R. Dos santos Morais, 30/11/2017, 4... Christian Griesinger, November 24th... Takahiro Muraoka, 16/11/2017, 11am,... Vladimir Torbeev, 9/11/2017, 2pm, E... M. D. Smith & T.Constantieux, 3/11/... James Nowick, 15 september 2017, 11... Emmanuelle Thinon, 28 June 2017, 11... Caroline Tokarski, 15 June 2017, 4p... Christian Salesse, 8 June 2017, 4pm... Patrice Rey, 01 June 2017, 2h30 pm,... Christina Sizun, 18 May 2017, 4 pm,... Marisela Velez, 5 May 2017, 11am, I... Iqbal Choudhary, 27 April 2017, 4 p... Vincent Aucagne, 21 April 2017, 11 ... Sophie Zinn-Justin, 14 April 2017, ... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
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Patricia DULOR Anthony BOUTER Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Yann FERRAND Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

A great advance on the cellular toxicity of Alzheimer’s disease



Although central to Alzheimer's disease, the toxicity of Aβ remained poorly understood. Researchers at the Institute of Chemistry and Biology of membranes and nanoobjects (CBMN, CNRS / University of Bordeaux / Bordeaux INP) and the Universities of Freiburg and Leuven have used a yeast model system to demonstrate that Aß targets the plasma membranes of cells. This work, published in the journal Frontiers in Molecular Neuroscience, should help control, and especially reduce, these toxic interactions.

 

Alzheimer's disease is characterized by the aggregation of amyloid beta (Aβ) inside and outside the neurons, leading to the formation of large amyloid plaques. Understanding the action of this peptide is therefore a crucial step in the study of this pathology. For this purpose, scientists from the Institute of Chemistry and Biology of membranes and nanoobjects (CBMN, CNRS / University of Bordeaux / Bordeaux INP) and Universities of Freiburg and Leuven have monitored the toxicity of Aß on a simple eukaryotic model. The model chosen, S. cerevisiae, indeed has a large number of genes in common with humans and is a convenient platform to study the molecular processes that are related to complex diseases.


Researchers have shown that cells can manage Aß accumulation in their endoplasmic reticulum, a membrane structure intermediate between the nucleus and the outer membrane. They then challenged the toxicity of Aß with a library of knockout yeasts spanning the entire genome. They could identify KO strains that could no longer compensate for the damage caused by Aβ (which then accumulated on the plasma membrane) and exhibited a drastic increase in peptide toxicity. It is thus problems of expression of the protective and repairing genes of the plasma membrane that influence the cellular toxicity of Aβ. The BRO1 gene, whose human equivalent is Alix (encoding for a protein found in amyloid plaques), is thus particularly important for protecting cells. This finding opens plethora of questions, and researchers can now study these biochemical interactions in the hope of controlling the deleterious effects.

 

 

 

Reference: Gernot Fruhmann, Christelle Marchal, Hélène Vignaud, Mathias Verduyckt, Nicolas Talarek, Claudio De Virgilio, Joris Winderickx et Christophe Cullin


The impact of ESCRT-III on amyloid ß1-42 mediated membrane lesions in a humanized yeast model.
Frontiers in Molecular NeuroscienceNovember 2018
DOI: 10.3389/fnmol.2018.00406

 

Researcher contact : Christophe Cullin, CBMN UMR5248, Université de Bordeaux, Bordeaux INP
E-mail : christophe.cullin@u-bordeaux.fr
Phone : +33(0)5 40 00 68 48

 

Publication on www.cnrs.fr:

http://www.cnrs.fr/inc/communication/direct_labos/cullin.htm

 

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