Institut de Chimie & Biologie des Membranes & des Nano-objets • Bordeaux

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Emmanuelle Thinon, 28 June 2017, 11 am, IECB Caroline Tokarski, 15 June 2017, 4pm, ENSCBP Christian Salesse, 8 June 2017, 4pm, ENSCBP Patrice Rey, 01 June 2017, 2h30 pm, ENSCBP Christina Sizun, 18 May 2017, 4 pm, ENSCBP Marisela Velez, 5 May 2017, 11am, IECB Iqbal Choudhary, 27 April 2017, 4 pm, ENSCBP Vincent Aucagne, 21 April 2017, 11 am, IECB Sophie Zinn-Justin, 14 April 2017, 11 am, IECB Cécile Feuillie, 16 February 2017, 4 PM, ENSCBP Félix M. Goñi, 8 december 2016, 4 pm, ENSCBP Félix M. Goñi, 17 november 2016, 4 pm, ENSCBP Carl Creutz, 20 october 2016, 4 pm, ENSCBP Diego Romero, 30 september 2016, 11 am, IECB A. Ciaccafava, 8 september 2016, 14h, ENSCBP A. Ramamoorthy, 16 June 2016, 16h, ENSCBP Alexandre de Brevern, 2 june 2016, ENSCBP Isabelle Landrieu, 26 May, 16h, ENSCBP Frances Sepavoric, 12 May, 16h, ENSCBP Thomas Pradeu, 7 April 2016, 9h, ENSCBP Françoise Argoul, 3 march 2016, 16h, ENSCBP Corinne Loutelier-Bourhis, 16/12/2015, 16h Aristotelis XENAKIS, 3 december 2015, 16h Fabian Kiessling, 26 november 2015, 11h Michaël Molinari, 20 november 2015, 11h Dipankar Das Sarma, 28 October 2015, 14h. Olivier Donard, 22 october 2015, 16h, ENSCBP E. Morvan & A.Grelard, 17/12/2015, 16h, ENSCBP Christophe Cullin, 10 september 2015, 14 h Brigitte Lindet, 18 June 2015, 16h, ENSCBP(B) Marion Decossas, 4 June 2015, 16h, ENSCBP(B) Pascale Schellenberger, 21 Mai 2015, 16h F. Leal-Calderon, 7 May 2015, 16h, ENSCBP(B) Ibrahim Abdulhalim, 9 April 2015, 14h, ENSCBP Manon Carré, 26 March 2015, 14h, ENSCBP(B) C. Bure & JM Schmitter, 19 March 2015, 16h T. Ogata & H. Ihara, 17 March 2015, 11h, IECB Banafshe Larijani, 12 March 2015, 16h, ENSCBP
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Emmanuelle Thinon, 28 June 2017, 11... Caroline Tokarski, 15 June 2017, 4p... Christian Salesse, 8 June 2017, 4pm... Patrice Rey, 01 June 2017, 2h30 pm,... Christina Sizun, 18 May 2017, 4 pm,... Marisela Velez, 5 May 2017, 11am, I... Iqbal Choudhary, 27 April 2017, 4 p... Vincent Aucagne, 21 April 2017, 11 ... Sophie Zinn-Justin, 14 April 2017, ... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
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Patricia DULOR Alain BRISSON Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Ivan HUC Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

Frances Sepavoric, 12 May, 16h, ENSCBP

 

The seminar will take place, the 12th of May at 16h, at the  ENSCBP amphitheater, Building B,  allée Geoffroy Saint-Hilaire, Pessac.

 

The mechanism and membrane selectivity of the antimicrobial peptide maculatin 1.1

 

Professor Frances Separovic FAA

School of Chemistry, University of Melbourne, Autralia

 

ABSTRACT

 

Antimicrobial peptides (AMP) present an alternative to conventional antibiotics but details of their mechanism of action and the basis for differences in potency observed between different bacterial strains remain unclear. Structural information is crucial for defining the molecular mechanism by which these peptides recognize and interact with a particular lipid membrane.

 

We present NMR structural investigations of the AMP maculatin 1.1 in different lipid systems. Although the AMP is α-helical, the degree of helicity depended on membrane curvature and surface charge with a greater helical stretch in bicelles compared to micelles. The central core of maculatin was mainly transmembrane in bicelles while the N-terminus was exposed in micelles. MD simulations also showed N-terminal exposure to the solvent and indicated that maculatin bent to adapt to the micelle curvature. Maculatin induced greater headgroup and acyl-chain perturbations for anionic phospholipids in anisotropic bicelles; and appeared to lie on the surface of charged lipid membranes but insert in a transmembrane fashion with neutral membranes. Overall, lipid composition plays a critical role in modulating AMP structure and function.

Short CV

 

Professor Frances Separovic is a Biophysical Chemist and Head of the School of Chemistry, University of Melbourne. Frances completed a BA at Macquarie University and a PhD at University of New South Wales while working at CSIRO, Sydney. Following a post-doctoral fellowship at National Institutes of Health (USA), Frances joined the University of Melbourne in 1996. Frances has developed solid-state NMR techniques to determine the structure and dynamics of membrane components in situ, specializing in peptide antibiotics and toxins within phospholipid membranes. Her lab, which specializes in membrane biophysics and biological solid-state NMR, is based at the Bio21 Institute, University of Melbourne.

 

Frances has served as Assistant Dean (EO) (2001-02) and Associate Dean (2009-10) of the Science Faculty and General Treasurer of the Royal Australian Chemical Institute (2008-10). She was elected to Council of the Biophysical Society (USA) for 2007-10; Treasurer of Lorne Protein Conference (2006-09), Council of International Union of Pure & Applied Biophysics, IUPAB (2002-05); President of Australian Society for Biophysics, ASB (1999-2001, 2012-14); President of Australian New Zealand Society for Magnetic Resonance, ANZMAG (2011-13); and an editorial board member of Accounts of Chemical Research and editor of Biochimica Biophysica Acta – Biomembranes and European Biophysics Journal. Frances has organized 40 major scientific conferences and published over 180 papers in international journals. She was awarded the ASB Robertson Medal in 2009, the ANZMAG Medal in 2011 and was elected Fellow of the Biophysical Society (USA), ISMAR Fellow, and Fellow of the Australian Academy of Science in 2012. http://www.chemistry.unimelb.edu.au/professor-frances-separovic

 

Contact: Erick Dufourc, e.dufourc@cbmn.u-bordeaux.fr

 

 

 

 

 

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