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Christian Salesse, 8 June 2017, 4pm... Christina Sizun, 18 May 2017, 4 pm,... Marisela Velez, 5 May 2017, 11am, I... Iqbal Choudhary, 27 April 2017, 4 p... Vincent Aucagne, 21 April 2017, 11 ... Sophie Zinn-Justin, 14 April 2017, ... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
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Patricia DULOR Alain BRISSON Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Ivan HUC Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

Isabelle Landrieu, 26 May, 16h, ENSCBP

The seminar will take place, the 26th of May,at 16h, at the  ENSCBP amphitheater, Building B,  allée Geoffroy Saint-Hilaire, Pessac.

 

NMR study of the neuronal Tau protein

 

Isabelle Landrieu

UMR8576 CNRS-Lille University, F-59000 Lille, France.

 

abstract

 

Tau pathologies, called ‘tauopathies’, are related to several neurodegenerative diseases including Alzheimer Disease (AD). In AD, Tau protein is observed hyper-phosphorylated and aggregated as Paired Helical Filament (PHF). The molecular mechanisms of Tau-linked neurodegeneration is far however from being elucidated. Tau is a paradigm for the growing class of “intrinsically disordered proteins”, often found associated with pathologies such as neurodegenerative diseases, hence increasing the interest to grasp the molecular parameters underlying their functions.

 

The fine structural characterization at the molecular level of Tau and its interactions remain challenging due to its highly dynamical character. Additionally, 80 Ser/Thr residues in the longest Tau isoform, potential sites of phosphorylation, can be combined to give a multiphosphorylated Tau, leading to a very complex regulation of Tau interactions. Nuclear Magnetic Resonance (NMR) Spectroscopy is used to define the phosphorylation pattern of Tau samples, to investigate the impact of specific patterns of phosphorylation on structural determinants of Tau and to characterize Tau interactions with its molecular partners and their regulations.

 

Comprehension of the dynamic combination of these aspects represents a huge task but will probably be the key to therapeutic intervention on Tau pathway.

 

Selected Publications related to the seminar

Qi H, et al., Landrieu I. Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase J. Biol Chem. 2016/A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein.Angew Chem Int Ed Engl. 2015/ Milroy LG, et al., Landrieu I, Ottmann C. Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew Chem Int Ed Engl. 2015/ Qi H, et al., Landrieu I. Nuclear Magnetic Resonance Spectroscopy characterization of Tau interaction with DNA and its regulation by phosphorylation. Biochemistry. 2015/Sibille N, et al., Landrieu I. Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein. Proteins 2011



Biography

Degrees

1993 Engineering degree (Applied Chemistry and Biotechnology) University of Liège, Gembloux, Belgium.

1997 PhD thesis in Agronomy and Biological engineering University of Liège, Gembloux, Belgium.

2003 Habilitation à Diriger des Recherches, Lille University, France

 

Career

PhD student at EMBL outstation in Grenoble (1994-1997)

Postdoctoral fellow at Plant System Biology Lab, Ghent, Belgium, Advisors D. Inzé and M. Von Montagu (1997-2001)

Scientist at CNRS since 2001, Present position: DR2, CNRS.

 

Contact: Christophe Cullin (c.cullin@cbmn.u-bordeaux.fr)

 

 

 

 

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