The seminar will take place, the 17th of november, at 4 pm, at the ENSCBP amphitheater, Building B, allée Geoffroy Saint-Hilaire, Pessac.
The seminar is open to Undergraduated and Graduated students
Félix M. Goñi, Professor
Unidad de Biofísica, University of the Basque Country, Spain
Visiting Professor (2016) of the University of Bordeaux, France
The fluid mosaic model of Singer and Nicolson (1972) is a commonly used representation of the cellmembrane structure and dynamics. However a number of features, the result of four decades of research, must be incorporated to obtain a valid, contemporary version of the model. Among the novel aspects to be considered are: (i) the high density of proteins in the bilayer, that makes the bilayer a molecularly “crowded” space, with important physiological consequences; (ii) the proteins that bind the membranes on a temporary basis, thus establishing a continuum between the purely soluble proteins, never in contact with membranes, and those who cannot exist unless bilayer-bound; (iii) the progress in our knowledge of lipid phases, the putative presence of non-lamellar intermediates in membranes, and the role of membrane curvature and its relation to lipid geometry, (iv) the existence of lateral heterogeneity (domain formation) in cellmembranes, including the transient microdomains known as rafts, and (v) the possibility of transient and localized transbilayer (flip-flop) lipid motion.
Félix M. Goñi (San Sebastián, Spain, 1951) earned his MD in Navarra (1975) and became interested in Biophysics during summer courses at the Gulbekian Foundation (Oeiras, Portugal) under N. van Uden. His post-doctoral work under D. Chapman (Royal Free Hospital, London) involved studies of lipid-protein interactions in membranes. From 1984 he has been a full Professor of Biochemistry at the University of the Basque Country (Bilbao, Spain). His research deals with molecular interactions in membranes, with particular attention to lipids and detergents. In 1999 he founded the Unidad de Biofísica, a joint centre of the University of the Basque Country and the Spanish National Research Council (CSIC), and has been Head of this institute from 2002 to 2015. He has chaired the Publications Committee of FEBS (2006-2011) and the International Relations Committee of the U.S. Biophysical Society (2011-2016). He was President of the Spanish Biophysical Society (1992-1998), who made him a Honorary Member in 2011. In 2013 he was awarded the Avanti-EBSA Lipid Award, and was made a Honorary Member of the Spanish Biochemical Society. He is currently President of the Spanish Biochemical Society.
Contact: Erick Dufourc, firstname.lastname@example.org