The seminar will take place, the 8th of december at 4 pm, at the ENSCBP amphitheater, Building B, allée Geoffroy Saint-Hilaire, Pessac.
The seminar is open to Undergraduated and Graduated students
Félix M. Goñi, Professor
Unidad de Biofísica, University of the Basque Country, Spain
Visiting Professor (2016) of the University of Bordeaux, France
The available data concerning the ability of ceramide and other simple sphingolipids to segregate laterally into rigid, gel-like domains in a fluid bilayer will be reviewed. Ceramides give rise to rigid ceramide-enriched domains when their N-acyl chain is longer than C12. The high melting temperature of hydrated ceramides, revealing a tight intermolecular interaction, is probably responsible for their lateral segregation. Ceramides compete with cholesterol for the formation of domains with lipids such as sphingomyelin or saturated phosphatidylcholines; under these conditions displacement of cholesterol by ceramide involves a transition from a liquid-ordered to a gel-like phase in the domains involved. When ceramide is generated in situ by a sphingomyelinase, instead of being premixed with the other lipids, gel-like domain formation occurses well, although the topology of the domains may not be the same, the enzyme causing clustering of domains that is not detected with premixed ceramide. Ceramide-1-phosphate is not likely to form domains in fluid bilayers, and the same is true of sphingosine and of sphingosine-1-phosphate. However, sphingosine does rigidify pre-existing gel domains in mixed bilayers.
Félix M. Goñi (San Sebastián, Spain, 1951) earned his MD in Navarra (1975) and became interested in Biophysics during summer courses at the Gulbekian Foundation (Oeiras, Portugal) under N. van Uden. His post-doctoral work under D. Chapman (Royal Free Hospital, London) involved studies of lipid-protein interactions in membranes. From 1984 he has been a full Professor of Biochemistry at the University of the Basque Country (Bilbao, Spain). His research deals with molecular interactions in membranes, with particular attention to lipids and detergents. In 1999 he founded the Unidad de Biofísica, a joint centre of the University of the Basque Country and the Spanish National Research Council (CSIC), and has been Head of this institute from 2002 to 2015. He has chaired the Publications Committee of FEBS (2006-2011) and the International Relations Committee of the U.S. Biophysical Society (2011-2016). He was President of the Spanish Biophysical Society (1992-1998), who made him a Honorary Member in 2011. In 2013 he was awarded the Avanti-EBSA Lipid Award, and was made a Honorary Member of the Spanish Biochemical Society. He is currently President of the Spanish Biochemical Society.
Contact: Erick Dufourc, firstname.lastname@example.org