Institut de Chimie & Biologie des Membranes & des Nano-objets • Bordeaux

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Sophie Zinn-Justin, 14 April 2017, 11 am, IECB Christina Sizun, 18 May 2017, 4 pm, ENSCBP Cécile Feuillie, 16 February 2017, 4 PM, ENSCBP Félix M. Goñi, 8 december 2016, 4 pm, ENSCBP Félix M. Goñi, 17 november 2016, 4 pm, ENSCBP Carl Creutz, 20 october 2016, 4 pm, ENSCBP Diego Romero, 30 september 2016, 11 am, IECB A. Ciaccafava, 8 september 2016, 14h, ENSCBP A. Ramamoorthy, 16 June 2016, 16h, ENSCBP Alexandre de Brevern, 2 june 2016, ENSCBP Isabelle Landrieu, 26 May, 16h, ENSCBP Frances Sepavoric, 12 May, 16h, ENSCBP Thomas Pradeu, 7 April 2016, 9h, ENSCBP Françoise Argoul, 3 march 2016, 16h, ENSCBP Corinne Loutelier-Bourhis, 16/12/2015, 16h Aristotelis XENAKIS, 3 december 2015, 16h Fabian Kiessling, 26 november 2015, 11h Michaël Molinari, 20 november 2015, 11h Dipankar Das Sarma, 28 October 2015, 14h. Olivier Donard, 22 october 2015, 16h, ENSCBP E. Morvan & A.Grelard, 17/12/2015, 16h, ENSCBP Christophe Cullin, 10 september 2015, 14 h Brigitte Lindet, 18 June 2015, 16h, ENSCBP(B) Marion Decossas, 4 June 2015, 16h, ENSCBP(B) Pascale Schellenberger, 21 Mai 2015, 16h F. Leal-Calderon, 7 May 2015, 16h, ENSCBP(B) Ibrahim Abdulhalim, 9 April 2015, 14h, ENSCBP Manon Carré, 26 March 2015, 14h, ENSCBP(B) C. Bure & JM Schmitter, 19 March 2015, 16h T. Ogata & H. Ihara, 17 March 2015, 11h, IECB Banafshe Larijani, 12 March 2015, 16h, ENSCBP
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Sophie Zinn-Justin, 14 April 2017, ... Christina Sizun, 18 May 2017, 4 pm,... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
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Patricia DULOR Alain BRISSON Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Ivan HUC Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

Félix M. Goñi, 8 december 2016, 4 pm, ENSCBP

The seminar will take place, the 8th of december at 4 pm, at the  ENSCBP amphitheater, Building B,  allée Geoffroy Saint-Hilaire, Pessac.

The seminar is open to Undergraduated and Graduated students

 

Biophysical properties of ceramides, from the nano to the microscale

 

Félix M. Goñi, Professor

Unidad de Biofísica, University of the Basque Country, Spain

Visiting Professor (2016) of the University of Bordeaux, France

 

Abstract

 

The available data concerning the ability of ceramide and other simple sphingolipids to segregate laterally into rigid, gel-like domains in a fluid bilayer will be reviewed.  Ceramides give rise to rigid ceramide-enriched domains when their N-acyl chain is longer than C12. The high melting  temperature of hydrated ceramides, revealing a tight intermolecular interaction, is probably  responsible for their lateral segregation. Ceramides compete with cholesterol for the formation of domains with lipids such as sphingomyelin or saturated phosphatidylcholines; under these conditions displacement of  cholesterol by ceramide involves a transition from a liquid-ordered to a gel-like phase in the domains involved. When ceramide is generated in situ by a sphingomyelinase, instead of being premixed with the other lipids, gel-like domain formation occurses well, although the topology of the domains may not be the same, the  enzyme causing clustering of domains that is not detected with premixed ceramide. Ceramide-1-phosphate is not likely to form domains in fluid bilayers, and the same is true of sphingosine and of  sphingosine-1-phosphate. However, sphingosine does rigidify pre-existing gel domains in mixed bilayers.

 

Short CV

 

Félix M. Goñi (San Sebastián, Spain, 1951) earned his MD in Navarra (1975) and became interested in Biophysics during summer courses at the Gulbekian Foundation (Oeiras, Portugal) under N. van Uden. His post-doctoral work under D. Chapman (Royal Free Hospital, London) involved studies of lipid-protein interactions in membranes. From 1984 he has been a full Professor of Biochemistry at the University of the Basque Country (Bilbao, Spain). His research deals with molecular interactions in membranes, with particular attention to lipids and detergents. In 1999 he founded the Unidad de Biofísica, a joint centre of the University of the Basque Country and the Spanish National Research Council (CSIC), and has been Head of this institute from 2002 to 2015. He has chaired the Publications Committee of FEBS (2006-2011) and the International Relations Committee of the U.S. Biophysical Society (2011-2016). He was President of the Spanish Biophysical Society (1992-1998), who made him a Honorary Member in 2011. In 2013 he was awarded the Avanti-EBSA Lipid Award, and was made a Honorary Member of the Spanish Biochemical Society. He is currently President of the Spanish Biochemical Society.

 

Contact: Erick Dufourc, e.dufourc@cbmn.u-bordeaux.fr

 

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