The seminar will take place, the 16th of February 2017, at 4 pm, at the ENSCBP amphitheater, Building B, allée Geoffroy Saint-Hilaire, Pessac.
Atomic Force Microscopy for microbiology
Dr Cecile FEUILLIE, Postdoc
Université Catholique de Louvain
Atomic Force Microscopy (AFM) has become a powerful tool in microbiology, as it provides the possibility to study live bacterial cells in physiological conditions. An increasing number of AFM-based techniques have allowed the high-resolution imaging and characterization of bacteria at the nanoscale, as well as the direct measurement of the forces involved in bacterial interactions. Nanomedicine can directly benefit from these advances, notably in the fight against S. aureus biofilm-associated nosocomial infections. Indeed, AFM allows the characterization of the specific interactions at stake in the first steps of biofilm formation – cellular adhesion and cellular interactions –, contributing to the development of new anti-adhesive strategies as alternatives to antibiotics. In addition, recent developments in high-speed AFM enable the study of dynamic processes such as amyloid fibers growth, such as curli involved in E. coli biofilms. In this talk I will present recent results obtained at the Université Catholique de Louvain (Belgium), in collaboration with Trinity College Dublin and Vrije Universiteit Brussel.
After a master’s in Physics and Chemistry of the Earth and planets, Cecile Feuillie obtained her PhD in September 2012 at the Geology laboratory of the Ecole Normale Superieure de Lyon, working about the detection of degraded nucleic acids by SERRS spectroscopy and the interactions between nucleotides and Fe-Mg rich phyllosilicates in the context of the origin of Life. She then spent 2 ½ years as a postdoc at the Geophysical laboratory, Carnegie Institution of Washington (D.C., USA), where she pursued the study of the interaction between organics and oxide surfaces, using experimental and modeling approaches. She is now a postdoc at the Universite Catholique de Louvain in Yves Dufrene’s bio-AFM group, where she is using AFM to better understand bacterial adhesion, especially in the context of biofilm formation.
Contact: Sophie Lecomte, email@example.com