Institut de Chimie & Biologie des Membranes & des Nano-objets • Bordeaux

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Christian Griesinger, November 24th, 11am, IECB R. Dos santos Morais, 30/11/2017, 4 PM, ENSCBP Takahiro Muraoka, 16/11/2017, 11am, ENSCBP Vladimir Torbeev, 9/11/2017, 2pm, ENSCBP M. D. Smith & T.Constantieux, 3/11/2017, 2h30 pm, IECB James Nowick, 15 september 2017, 11am, IECB Emmanuelle Thinon, 28 June 2017, 11 am, IECB Caroline Tokarski, 15 June 2017, 4pm, ENSCBP Christian Salesse, 8 June 2017, 4pm, ENSCBP Patrice Rey, 01 June 2017, 2h30 pm, ENSCBP Christina Sizun, 18 May 2017, 4 pm, ENSCBP Marisela Velez, 5 May 2017, 11am, IECB Iqbal Choudhary, 27 April 2017, 4 pm, ENSCBP Vincent Aucagne, 21 April 2017, 11 am, IECB Sophie Zinn-Justin, 14 April 2017, 11 am, IECB Cécile Feuillie, 16 February 2017, 4 PM, ENSCBP Félix M. Goñi, 8 december 2016, 4 pm, ENSCBP Félix M. Goñi, 17 november 2016, 4 pm, ENSCBP Carl Creutz, 20 october 2016, 4 pm, ENSCBP Diego Romero, 30 september 2016, 11 am, IECB A. Ciaccafava, 8 september 2016, 14h, ENSCBP A. Ramamoorthy, 16 June 2016, 16h, ENSCBP Alexandre de Brevern, 2 june 2016, ENSCBP Isabelle Landrieu, 26 May, 16h, ENSCBP Frances Sepavoric, 12 May, 16h, ENSCBP Thomas Pradeu, 7 April 2016, 9h, ENSCBP Françoise Argoul, 3 march 2016, 16h, ENSCBP Corinne Loutelier-Bourhis, 16/12/2015, 16h Aristotelis XENAKIS, 3 december 2015, 16h Fabian Kiessling, 26 november 2015, 11h Michaël Molinari, 20 november 2015, 11h Dipankar Das Sarma, 28 October 2015, 14h. Olivier Donard, 22 october 2015, 16h, ENSCBP E. Morvan & A.Grelard, 17/12/2015, 16h, ENSCBP Christophe Cullin, 10 september 2015, 14 h Brigitte Lindet, 18 June 2015, 16h, ENSCBP(B) Marion Decossas, 4 June 2015, 16h, ENSCBP(B) Pascale Schellenberger, 21 Mai 2015, 16h F. Leal-Calderon, 7 May 2015, 16h, ENSCBP(B) Ibrahim Abdulhalim, 9 April 2015, 14h, ENSCBP Manon Carré, 26 March 2015, 14h, ENSCBP(B) C. Bure & JM Schmitter, 19 March 2015, 16h T. Ogata & H. Ihara, 17 March 2015, 11h, IECB Banafshe Larijani, 12 March 2015, 16h, ENSCBP
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Christian Griesinger, November 24th... R. Dos santos Morais, 30/11/2017, 4... Takahiro Muraoka, 16/11/2017, 11am,... Vladimir Torbeev, 9/11/2017, 2pm, E... M. D. Smith & T.Constantieux, 3/11/... James Nowick, 15 september 2017, 11... Emmanuelle Thinon, 28 June 2017, 11... Caroline Tokarski, 15 June 2017, 4p... Christian Salesse, 8 June 2017, 4pm... Patrice Rey, 01 June 2017, 2h30 pm,... Christina Sizun, 18 May 2017, 4 pm,... Marisela Velez, 5 May 2017, 11am, I... Iqbal Choudhary, 27 April 2017, 4 p... Vincent Aucagne, 21 April 2017, 11 ... Sophie Zinn-Justin, 14 April 2017, ... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
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Patricia DULOR Anthony BOUTER Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Yann FERRAND Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

M. D. Smith & T.Constantieux, 3/11/2017, 2h30 pm, IECB

The seminars will take place the 3rd of november 2017, at 2h30 pm and 3h15 pm, in the IECB amphitheatre, 2 rue Robert Escarpit Pessac.

 

Contact: Gilles Guichard, g.guichard@cbmn.u-bordeaux.fr

 

 

Talk 1 : Counter-ions and Cascades in Organic Synthesis

 

 Martin D. Smith, Professor

Department of Chemistry, University of Oxford,
12 Mansfield Road, Oxford OX1 3TA

 

martin.smith@chem.ox.ac.uk  http://msmith.chem.ox.ac.uk

 

Short Biography

 

Martin Smith is Professor of Organic Chemistry at the University of Oxford, and the Old Members' Helen Martin Fellow at University College, Oxford. He is also co-director of the CDT in Synthesis for Biology & Medicine. He came up to the University of Oxford from Middlesbrough for his undergraduate studies, then worked with Professor George W. J. Fleet on the chemistry of carbohydrate amino acids, gaining his DPhil in 1999/2000. He then moved to Pembroke College, University of Cambridge as the Drapers Company Research Fellow, to work with Professor Steven V. Ley CBE FRS. In 2003 he began his tenure as a Royal Society University Research Fellow in the Department of Chemistry, University of Cambridge. The group moved to the University of Oxford in October 2008.

 

Abstract

 

Counter-ions affect both the reactivity and selectivity of anionic reactions. In this lecture I will describe my group’s work on counter-ion-directed cyclization1 and mechanism2 and demonstrate how lessons learned in this area can be applied in the development of new enantioselective methods, with a particular focus on controlling axial chirality.3-5

 

 

 

Extension of this chemistry to complexity-generating reactions6 and cascade approaches to the total synthesis of complex natural products will also be outlined.7-9

 

References

 

1. Cation-controlled enantio- and diastereoselective synthesis of indolines:
an autoinductive phase–transfer initiated 5-endo-trig process, K. Sharma, J. R. Wolstenhulme, P. P. Painter, D. Yeo, F. Grande-Carmona, C. P. Johnston, D. J. Tantillo & M. D. Smith, J. Am. Chem. Soc. 2015, 137, 13414-13424.

2. Catalytic enantioselective synthesis of indanes by a cation-directed 5-endo-trig cyclization, C. P. Johnston, A. Kothari, T. Sergeieva, S. I. Okovytyy, K. E. Jackson, R. S. Paton & M. D. Smith, Nature. Chem.2015, 7, 171-176.

3. Catalytic enantioselective synthesis of atropisomeric biaryls: a cation-directed nucleophilic aromatic substitution reaction 
R. J. Armstrong & M. D Smith, Angew. Chem. Int. Ed. 2014, 53, 12822-12825.

4. Catalytic enantioselective synthesis of C1 and C2-symmetric spirobiindanones through counterion-directed enolate C-acylation, B. F. Rahemtulla, H. F. Clark & M. D. Smith, Angew. Chem. Int. Ed. 2016, 55, 13180-13183.

5. Catalytic enantioselective synthesis of atropisomeric biaryls by a cation-Ddrected O-alkylation, J. D. Jolliffe, R. J. Armstrong & M. D. Smith, Nature Chem. 2017,9, 558-563.

6. A counterion-directed approach to the Diels-Alder paradigm: cascade synthesis of tricyclic fused cyclopropanes, E. Kiss, C. D. Campbell, R. W. Driver, J. D. Jolliffe, R. Lang, T. Sergieiva, S, Okovytyy, R. S. Paton & M. D. Smith. Angew. Chem. Int. Ed. 2016, 55, 13813-13817.

7. A cascade strategy enables a total synthesis of gephyrotoxin, S. Chu, S. Wallace & M. D. Smith, Angew. Chem. Int. Ed. 2014, 53, 13826-13829.

8. A cascade strategy enables a total synthesis of morphine, S. Chu, N. Münster, T. Balan & M. D. Smith, Angew. Chem. Int. Ed. 2016, 55, 14306-14309.

9.Visible light photocatalysis of 6π heterocyclization,Niels Münster, Nicholas Parker, Lucy van Dijk, Robert S. Paton & Martin D. Smith, Angew. Chem. Int. Ed. 2017, 56, 9468-9472.

 

Talk 2 : Organocatalytic Domino and Multicomponent reactions of 1,3-Dicarbonyls for the Synthesis of Enantioenriched Heterocycles

 

Thierry Constantieux, Professor

ISM2 - Institut des Sciences Moléculaires de

Marseille, Aix-Marseille Université - Service 541, Marseille, France

thierry.constantieux@univ-amu.fr

 

short biography:

Thierry Constantieux was born in Pau (France) in 1968. After studying chemistry at the University Bordeaux I, he completed his Ph.D. under the supervision of Dr. J.-P. Picard and Dr. J. Dunoguez in 1994. In 1995, he was appointed as Assistant Professor at the University of Aix-Marseille III (France). He completed his Habilitation in 2004 at Aix-Marseille Université (France), where he is currently full Professor of Organic Chemistry. His main research interest is focused on the development of new eco-compatible synthetic methodologies, especially enantioselective organocatalyzed cascades and domino multicomponent reactions from 1,3-dicarbonyl compounds, and their applications in heterocyclic chemistry. Since 2012, he is the scientific coordinator of one of the four research teams (STEREO team, 14 permanent people) of « Institut des Sciences Moléculaires de Marseille » (iSm2). In 2015, he was elected as Director of the Doctoral School of Chemical Sciences, at Aix-Marseille Université.

 

Abstract

A general perspective of the research program aimed towards the preparation of polycyclic heterocycles by the means of enantioselective organocatalytic reactions will be presented. β- Dicarbonyl compounds are generally used as pronucleophiles in the synthesis of these heterocycles and their polyfunctional nature makes them ideal substrates for multiple- bond-forming transformations (MBFTs) including domino processes and multicomponent reactions.

 

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