Institut de Chimie & Biologie des Membranes & des Nano-objets • Bordeaux

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O.Reinaud & V. Artero, 7/12/2017, 10 am, IECB R. Dos santos Morais, 30/11/2017, 4 PM, ENSCBP Christian Griesinger, November 24th, 11am, IECB Takahiro Muraoka, 16/11/2017, 11am, ENSCBP Vladimir Torbeev, 9/11/2017, 2pm, ENSCBP M. D. Smith & T.Constantieux, 3/11/2017, 2h30 pm, IECB James Nowick, 15 september 2017, 11am, IECB Emmanuelle Thinon, 28 June 2017, 11 am, IECB Caroline Tokarski, 15 June 2017, 4pm, ENSCBP Christian Salesse, 8 June 2017, 4pm, ENSCBP Patrice Rey, 01 June 2017, 2h30 pm, ENSCBP Christina Sizun, 18 May 2017, 4 pm, ENSCBP Marisela Velez, 5 May 2017, 11am, IECB Iqbal Choudhary, 27 April 2017, 4 pm, ENSCBP Vincent Aucagne, 21 April 2017, 11 am, IECB Sophie Zinn-Justin, 14 April 2017, 11 am, IECB Cécile Feuillie, 16 February 2017, 4 PM, ENSCBP Félix M. Goñi, 8 december 2016, 4 pm, ENSCBP Félix M. Goñi, 17 november 2016, 4 pm, ENSCBP Carl Creutz, 20 october 2016, 4 pm, ENSCBP Diego Romero, 30 september 2016, 11 am, IECB A. Ciaccafava, 8 september 2016, 14h, ENSCBP A. Ramamoorthy, 16 June 2016, 16h, ENSCBP Alexandre de Brevern, 2 june 2016, ENSCBP Isabelle Landrieu, 26 May, 16h, ENSCBP Frances Sepavoric, 12 May, 16h, ENSCBP Thomas Pradeu, 7 April 2016, 9h, ENSCBP Françoise Argoul, 3 march 2016, 16h, ENSCBP Corinne Loutelier-Bourhis, 16/12/2015, 16h Aristotelis XENAKIS, 3 december 2015, 16h Fabian Kiessling, 26 november 2015, 11h Michaël Molinari, 20 november 2015, 11h Dipankar Das Sarma, 28 October 2015, 14h. Olivier Donard, 22 october 2015, 16h, ENSCBP E. Morvan & A.Grelard, 17/12/2015, 16h, ENSCBP Christophe Cullin, 10 september 2015, 14 h Brigitte Lindet, 18 June 2015, 16h, ENSCBP(B) Marion Decossas, 4 June 2015, 16h, ENSCBP(B) Pascale Schellenberger, 21 Mai 2015, 16h F. Leal-Calderon, 7 May 2015, 16h, ENSCBP(B) Ibrahim Abdulhalim, 9 April 2015, 14h, ENSCBP Manon Carré, 26 March 2015, 14h, ENSCBP(B) C. Bure & JM Schmitter, 19 March 2015, 16h T. Ogata & H. Ihara, 17 March 2015, 11h, IECB Banafshe Larijani, 12 March 2015, 16h, ENSCBP
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O.Reinaud & V. Artero, 7/12/2017, 1... R. Dos santos Morais, 30/11/2017, 4... Christian Griesinger, November 24th... Takahiro Muraoka, 16/11/2017, 11am,... Vladimir Torbeev, 9/11/2017, 2pm, E... M. D. Smith & T.Constantieux, 3/11/... James Nowick, 15 september 2017, 11... Emmanuelle Thinon, 28 June 2017, 11... Caroline Tokarski, 15 June 2017, 4p... Christian Salesse, 8 June 2017, 4pm... Patrice Rey, 01 June 2017, 2h30 pm,... Christina Sizun, 18 May 2017, 4 pm,... Marisela Velez, 5 May 2017, 11am, I... Iqbal Choudhary, 27 April 2017, 4 p... Vincent Aucagne, 21 April 2017, 11 ... Sophie Zinn-Justin, 14 April 2017, ... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
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Patricia DULOR Anthony BOUTER Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Yann FERRAND Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

Christian Griesinger, November 24th, 11am, IECB

The seminar will take place, the 24th of november 2017, at 11 am, in the IECB amphitheatre, 2 rue Robert Escarpit Pessac.

 

Pr. Christian Griesinger

Dept. for NMR-based Struct. Biology, Max-Planck Institute for Biophysical Chemistry

DFG-Center for the Molecular Physiology of the Brain, Göttingen

 

NMR spectroscopy to study dynamics with applications to immunology and neurodegeneration

 

 

S. Prathihar1, C. Smith1,2, J. Reddy1, T.M. Sabo1, L. Wong1, L. Russo1, J. Kühn3, S. Pirkuliyeva3, D. Lee1, T.M. Sabo1, S. Ryzanov1,4, L. Antonschmidt1,4, A. Martinez Hernandez5, H.Y. Agbemenyah6, S. Shi7, A. Fischer6, G. Eichele5, D. Lee1, S. Becker1, A. Leonov1,4, R. Benz8, M. Zweckstetter1,4, J. Wienands3, A. Giese7, and C. Griesinger1,4

 

1Dept. for NMR-based Struct. Biology, Max-Planck Institute for Biophysical Chemistry; 3Institute of Cellular and Molecular Immunology, Georg August University of Göttingen, Göttingen; 4DFG-Center for the Molecular Physiology of the Brain, Göttingen; 5Genes and Behavior Dept., Max-Planck Institute for Biophysical Chemistry, Göttingen; 6 European Neuroscience Institute Göttingen;, 7 Center for Neuropathology and prion research, LMU, Munich, Germany; 8 Jacobs University of Bremen, Germany
 

Abstract

 

 

Kinetics of protein dynamics will be discussed on examples of folded on unfolded proteins (1). The role of partially disordered proteins in two fields of research is investigated. One is the adaptor protein SLP65 which interacts with CIN85 (2). The two proteins are essential for B cell activation. The protein is found to be mainly unstructured and its various segments entertain different functions or interact with membranes, SH3 domains and forming coiled coils. Based on the structures, a molecular lego will be described that reduces the SLP65/CIN85 interaction to its absolutely necessary essentials. The two proteins can perform phase separation which is related to function.

 

We are additionally interested in a class of IDPs that are important in neuro- and cellular degeneration, which form oligomers and fibrils. Interference with these aggregates specifically on the oligomer level proves to be a valid concept for treatment of devastating diseases such as Parkinson’s, Alzheimer’s, Creutzfeldt Jacob disease and Type II diabetes mellitus (3). Suprising links to some cancers can be identified which will be also be discussed in the lecture (4).

 

(1) C. Smith et al. Proc. Natl. Acad. Sci. USA. 113, 3296-74 (2016); C. Smith et al. Angew. Chem. Int. Ed. 54, 207-10 (2015)
(2) M. Engelke et al. Science signaling: 7 (339) ra79 (2014); J. Kühn et al. Science signaling: 9 (434) ra66 (2016)
(3) C.W. Bertoncini et al. PNAS 102, 1430-1435 (2005); P. Karpinar et al. EMBO J 28, 3256-3268 (2009); J. Wagner et al. Acta Neuropath. 125, 795-813 (2013); A.A. Deeg, Biochim. Biophys. Act. 1850 (9), 1884-1890 (2015); S. Shi, J. Neuropath. Exp. Neurol. 74(9) 924-933 (2015); J. Wagner et al. Act. Neuropath.130, 619-631 (2015)
(4) E. Turriani, et al. Proc. Natl. Acad. Sci. USA 114, E4971-E4977 (2017)

 

Contacts: Birgit Habenstein, b.habenstein@iecb.u-bordeaux.fr, Antoine Loquet, a.loquet@iecb.u-bordeaux.fr

 

 

 

 

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