Institut de Chimie & Biologie des Membranes & des Nano-objets • Bordeaux

LIA France-Japan GEM Réseau RMN Aquitain Master AC2QMAPS IPEP master UREKA UMT FOLIES INDIA
Offres d'Emploi Plateau Technique Conseil d'Unité Animation Scientifique WEB Editorial Committee Hygiène & Sécurité Communication Administration Directoire Scientifique Direction
James Nowick, 15 september 2017, 11am, IECB Emmanuelle Thinon, 28 June 2017, 11 am, IECB Caroline Tokarski, 15 June 2017, 4pm, ENSCBP Christian Salesse, 8 June 2017, 4pm, ENSCBP Patrice Rey, 01 June 2017, 2h30 pm, ENSCBP Christina Sizun, 18 May 2017, 4 pm, ENSCBP Marisela Velez, 5 May 2017, 11am, IECB Iqbal Choudhary, 27 April 2017, 4 pm, ENSCBP Vincent Aucagne, 21 April 2017, 11 am, IECB Sophie Zinn-Justin, 14 April 2017, 11 am, IECB Cécile Feuillie, 16 February 2017, 4 PM, ENSCBP Félix M. Goñi, 8 december 2016, 4 pm, ENSCBP Félix M. Goñi, 17 november 2016, 4 pm, ENSCBP Carl Creutz, 20 october 2016, 4 pm, ENSCBP Diego Romero, 30 september 2016, 11 am, IECB A. Ciaccafava, 8 september 2016, 14h, ENSCBP A. Ramamoorthy, 16 June 2016, 16h, ENSCBP Alexandre de Brevern, 2 june 2016, ENSCBP Isabelle Landrieu, 26 May, 16h, ENSCBP Frances Sepavoric, 12 May, 16h, ENSCBP Thomas Pradeu, 7 April 2016, 9h, ENSCBP Françoise Argoul, 3 march 2016, 16h, ENSCBP Corinne Loutelier-Bourhis, 16/12/2015, 16h Aristotelis XENAKIS, 3 december 2015, 16h Fabian Kiessling, 26 november 2015, 11h Michaël Molinari, 20 november 2015, 11h Dipankar Das Sarma, 28 October 2015, 14h. Olivier Donard, 22 october 2015, 16h, ENSCBP E. Morvan & A.Grelard, 17/12/2015, 16h, ENSCBP Christophe Cullin, 10 september 2015, 14 h Brigitte Lindet, 18 June 2015, 16h, ENSCBP(B) Marion Decossas, 4 June 2015, 16h, ENSCBP(B) Pascale Schellenberger, 21 Mai 2015, 16h F. Leal-Calderon, 7 May 2015, 16h, ENSCBP(B) Ibrahim Abdulhalim, 9 April 2015, 14h, ENSCBP Manon Carré, 26 March 2015, 14h, ENSCBP(B) C. Bure & JM Schmitter, 19 March 2015, 16h T. Ogata & H. Ihara, 17 March 2015, 11h, IECB Banafshe Larijani, 12 March 2015, 16h, ENSCBP
Événements Nouveau
Partenariat Congés Formation Admin CBMN Conseil Institut/Scientifique
Affiliations Les sites CBMN
LIA France-Japan GEM Réseau RMN Aquitain Master AC2QMAPS IPEP master UREKA UMT FOLIES INDIA
Offres d'Emploi Plateau Technique Conseil d'Unité Animation Scientifique WEB Editorial Committee Hygiène & Sécurité Communication Administration Directoire Scientifique Direction
Chimie Biophysique Chimie Biomimétique et Thérapeuti... Biologie et Biotechnologie Administration
James Nowick, 15 september 2017, 11... Emmanuelle Thinon, 28 June 2017, 11... Caroline Tokarski, 15 June 2017, 4p... Christian Salesse, 8 June 2017, 4pm... Patrice Rey, 01 June 2017, 2h30 pm,... Christina Sizun, 18 May 2017, 4 pm,... Marisela Velez, 5 May 2017, 11am, I... Iqbal Choudhary, 27 April 2017, 4 p... Vincent Aucagne, 21 April 2017, 11 ... Sophie Zinn-Justin, 14 April 2017, ... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
Événements Nouveau
Patricia DULOR Anthony BOUTER Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Yann FERRAND Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

RMN des Membranes et des Assemblages de Protéines

Our research focuses on structural biology and biophysics of biological assemblies, ranging from functional amyloids to bacterial nanomachines and lipid membranes. We develop and mainly apply solid-state NMR spectroscopy to capture structural and dynamic details at atomic resolution.

 

Our group manages the NMR facility of the IECB/CBMN, including 300, 400, 500, 600, 700 and to 800MHz NMR magnets, equipped with solution and solid-state NMR probes. The 800 MHz is part of the French NMR Large Scale Facilty (TGIR RMN THC). The Bordeaux site is specialized in NMR of biological assemblies, membranes, lipids and colloid science.

Main research topics:

 More details here:  http://www.loquetlab.org/

FUNCTIONAL AMYLOIDS

Amyloids are proteins that can form, under particular conditions, fibrillar aggregates (fibrils, oligomers). They are commonly associated with neurodegenerative diseases, such as Parkinson’s and Alzheimer’s diseases. Recently, such amyloid structures have been identified in programmed cell-death mechanisms. We aim at understanding the atomic architecture and study the structure-function relationship of several amyloid proteins involved in cell signaling.


SOLID-STATE NMR METHODOLOGY

Supramolecular assemblies are organized by a complex network of intermolecular interactions, controlling the assembly process and impacting the functions of the final assembled system.
We develop solid-state NMR methods to tackle complex molecular assemblies, to obtain atomic information on supramolecular interactions. Ultra-fast magic angle spinning NMR techniques are also investigated to improve sensitivity on complex biomolecular systems.

 

MEMBRANES AND LIPID INTERACTIONS

We use solid-state and solution NMR to study structural and dynamic aspects of membranes as well as their interactions with small organic molecules, peptides and proteins. The physical-chemistry of lipid assemblies is investigated. This includes the roles of various sterols in regulating membrane dynamics (order/disorder). Specific lipids involved in signaling (phosphoinositides, cardiolipins, DAG, …) are followed by 2H-NMR in natural membranes (viruses, tripanosomes).

 

TANNINS

We study tannin-lipid interactions in the field of oenology and health. In oenology, tannins are responsible for the astringency and the bitterness of red wines. The former implicates an interaction between tannins and saliva proteins during mouth lubrication, while the latter results from an interaction between tannins and taste receptors. We investigate tannin-lipid interactions and the anti-oxidant efficiency of tannins in membranes by liquid and solid-state NMR.

 

 

Site internet

Chef d'équipe

LOQUET Antoine

Antoine LOQUET

Chargé(e) de recherche

CBMN @ IECB

Institut Européen de Chimie et Biologie (IECB)

2 rue Robert Escarpit
33607 Pessac
Tel. : +33 (5) 40 00 30 38

Plan d'accès
Deuterium NMR of cholesterol embedded in liposmes & magnetic field orientable membranes
Deuterium NMR of cholesterol embedded in liposmes & magnetic field orientable membranes
Functional amyloids
Functional amyloids
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Services Direction Directoire Scientifique Administration Communication Hygiène & Sécurité WEB Editorial Committee Animation Scientifique Conseil d'Unité Plateau Technique Offres d'Emploi
EXT INDIA UMT FOLIES UREKA IPEP master Master AC2QMAPS Réseau RMN Aquitain GEM LIA France-Japan
Équipes Patricia DULOR Anthony BOUTER Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Yann FERRAND Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU
informations Mentions légales Plan d'accès Réalisation : Little Big Studio
Dernière mise à jour : 19/10/2017

CNRS Université de Bordeaux Institut Polytechnique de Bordeaux

CBMN Allée de Geoffroy St Hilaire Bât B14
33600 Pessac
Tél. : +33 (0)5 40 00 68 00
Fax : +33 (0)5 40 00 22 00
Mail : contact@cbmn.u-bordeaux.fr