Institut de Chimie & Biologie des Membranes & des Nano-objets • Bordeaux

LIA France-Japan GEM Réseau RMN Aquitain Master AC2QMAPS IPEP master UREKA UMT FOLIES INDIA
Plateau Technique Conseil d'Unité Animation Scientifique WEB Editorial Committee Hygiène & Sécurité Communication Administration Directoire Scientifique Direction
Internal CBMN Seminars: A. Baudin, 6 September 2018 Plateforme production de protéines, 5 juillet 2018, 14h, ENSTBB Patrick Trouillas, 21 June 2018, 2pm, ENSCBP Lucie Khemtemourian, 21 June 2018, 11am, IECB Jonathan Faherty, 7th June, 11 AM, IECB Yann Fichou, 3 May 2018, 2pm, IECB Internal CBMN seminars: A. Ciaccafava and G. Compain, 5 April 2018 Alain Roussel, 29/03/2018, 4 pm, ENSCBP Simon Poly, 22 march 2018, 2pm, ENSCBP J.Crassous, M. Sallé & A. Martinez, 18/12/2017, 10 am, IECB O.Reinaud & V. Artero, 7/12/2017, 10 am, IECB R. Dos santos Morais, 30/11/2017, 4 PM, ENSCBP Christian Griesinger, November 24th, 11am, IECB Takahiro Muraoka, 16/11/2017, 11am, ENSCBP Vladimir Torbeev, 9/11/2017, 2pm, ENSCBP M. D. Smith & T.Constantieux, 3/11/2017, 2h30 pm, IECB James Nowick, 15 september 2017, 11am, IECB Emmanuelle Thinon, 28 June 2017, 11 am, IECB Caroline Tokarski, 15 June 2017, 4pm, ENSCBP Christian Salesse, 8 June 2017, 4pm, ENSCBP Patrice Rey, 01 June 2017, 2h30 pm, ENSCBP Christina Sizun, 18 May 2017, 4 pm, ENSCBP Marisela Velez, 5 May 2017, 11am, IECB Iqbal Choudhary, 27 April 2017, 4 pm, ENSCBP Vincent Aucagne, 21 April 2017, 11 am, IECB Sophie Zinn-Justin, 14 April 2017, 11 am, IECB Cécile Feuillie, 16 February 2017, 4 PM, ENSCBP Félix M. Goñi, 8 december 2016, 4 pm, ENSCBP Félix M. Goñi, 17 november 2016, 4 pm, ENSCBP Carl Creutz, 20 october 2016, 4 pm, ENSCBP Diego Romero, 30 september 2016, 11 am, IECB A. Ciaccafava, 8 september 2016, 14h, ENSCBP A. Ramamoorthy, 16 June 2016, 16h, ENSCBP Alexandre de Brevern, 2 june 2016, ENSCBP Isabelle Landrieu, 26 May, 16h, ENSCBP Frances Sepavoric, 12 May, 16h, ENSCBP Thomas Pradeu, 7 April 2016, 9h, ENSCBP Françoise Argoul, 3 march 2016, 16h, ENSCBP Corinne Loutelier-Bourhis, 16/12/2015, 16h Aristotelis XENAKIS, 3 december 2015, 16h Fabian Kiessling, 26 november 2015, 11h Michaël Molinari, 20 november 2015, 11h Dipankar Das Sarma, 28 October 2015, 14h. Olivier Donard, 22 october 2015, 16h, ENSCBP E. Morvan & A.Grelard, 17/12/2015, 16h, ENSCBP Christophe Cullin, 10 september 2015, 14 h Brigitte Lindet, 18 June 2015, 16h, ENSCBP(B) Marion Decossas, 4 June 2015, 16h, ENSCBP(B) Pascale Schellenberger, 21 Mai 2015, 16h F. Leal-Calderon, 7 May 2015, 16h, ENSCBP(B) Ibrahim Abdulhalim, 9 April 2015, 14h, ENSCBP Manon Carré, 26 March 2015, 14h, ENSCBP(B) C. Bure & JM Schmitter, 19 March 2015, 16h T. Ogata & H. Ihara, 17 March 2015, 11h, IECB Banafshe Larijani, 12 March 2015, 16h, ENSCBP
Événements Nouveau
Partenariat Congés Formation Admin CBMN Conseil Institut/Scientifique
Affiliations Les sites CBMN
LIA France-Japan GEM Réseau RMN Aquitain Master AC2QMAPS IPEP master UREKA UMT FOLIES INDIA
Plateau Technique Conseil d'Unité Animation Scientifique WEB Editorial Committee Hygiène & Sécurité Communication Administration Directoire Scientifique Direction
Chimie Biophysique Chimie Biomimétique et Thérapeuti... Biologie et Biotechnologie Administration
Internal CBMN Seminars: A. Baudin, ... Plateforme production de protéine... Patrick Trouillas, 21 June 2018, 2p... Lucie Khemtemourian, 21 June 2018, ... Jonathan Faherty, 7th June, 11 AM, ... Yann Fichou, 3 May 2018, 2pm, IECB Internal CBMN seminars: A. Ciaccafa... Alain Roussel, 29/03/2018, 4 pm, EN... Simon Poly, 22 march 2018, 2pm, ENS... J.Crassous, M. Sallé & A. Martinez... O.Reinaud & V. Artero, 7/12/2017, 1... R. Dos santos Morais, 30/11/2017, 4... Christian Griesinger, November 24th... Takahiro Muraoka, 16/11/2017, 11am,... Vladimir Torbeev, 9/11/2017, 2pm, E... M. D. Smith & T.Constantieux, 3/11/... James Nowick, 15 september 2017, 11... Emmanuelle Thinon, 28 June 2017, 11... Caroline Tokarski, 15 June 2017, 4p... Christian Salesse, 8 June 2017, 4pm... Patrice Rey, 01 June 2017, 2h30 pm,... Christina Sizun, 18 May 2017, 4 pm,... Marisela Velez, 5 May 2017, 11am, I... Iqbal Choudhary, 27 April 2017, 4 p... Vincent Aucagne, 21 April 2017, 11 ... Sophie Zinn-Justin, 14 April 2017, ... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
Événements Nouveau
Patricia DULOR Anthony BOUTER Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Yann FERRAND Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU

Lucie Khemtemourian, 21 June 2018, 11am, IECB

The seminar  will take place the 21th of June 2018, at 11pm in the IECB amphitheatre, 2 rue Robert Escarpit Pessac.

 

Protein folding, misfolding and aggregation: the case of the islet amyloid polypeptide involved in type 2 diabetes mellitus.

 

 

Lucie Khemtemourian, researcher, CNRS

Sorbonne Université, UMR 7203, Laboratoire des Biomolécules, Paris.

 

Abstract

 

The aggregation of misfolded proteins into insoluble fibrils is a characteristic of more than 20 misfolding diseases, including type 2 diabetes mellitus (T2DM) Alzheimer’s disease, Parkinson’s disease and prion diseases. Amyloid formation in these diseases is strongly associated with cell death and loss of function of the tissue involved. One of the major challenges in biology today is to understand the intriguing processes of protein misfolding and aggregation that lead to disease. In these “protein misfolding” diseases, the native fold of a protein molecule changes (misfolds) through mostly unknown mechanisms, leading to increasing interaction with its companions and formation of aggregates.

 

T2DM is characterized metabolically by defects in insulin secretion, resulting in hyperglycemia, and is characterized histopathologically by the presence of fibrillar amyloid deposits in the pancreatic islets of Langerhans (islet amyloid). The presence of these amyloid deposits is thought to disrupt cell membranes leading to the death of the insulin producing islet β cells. Human islet amyloid polypeptide (hIAPP), a 37 amino acid peptide, is the major constituent of the amyloid deposits found in type 2 diabetic patients. hIAPP is co-produced and stored with insulin by the pancreatic islet β cells and is released in response to the stimuli that lead to insulin secretion. Accumulating evidence suggests that hIAPP amyloid deposits that accompany T2DM are not just an insignificant phenomenon derived from the disease progression, but that hIAPP aggregation induces processes that impair the functionality and the viability of β cells of pancreas.

 

In this talk, I will outline the crucial role of the amino acid composition in fibril formation and membrane interaction. I will explain the particular sequence/structure relationships of hIAPP which are likely to be essential in defining why some amyloids do form toxic amyloids for cells and others do not. In addition, I will give more insight into the molecular mechanism of early hIAPP aggregated species formation and of hIAPP-induced membrane disruption.

 

References

Hoffmann ARF, et al.Physical Chemistry and Chemical Physics, 2018, 20, 9561-9573.

Hoffmann ARF, et al.BBA-Biomembranes,2018, S0005-2736(18)30059-2.

Khemtemourian L, et al.Biochimie,2017, 142:22-30. DOI: 10.1016/j.biochi.2017.07.015.

Caillon L, et al. J Diabetes Res, 2016, 5639875

 

Short biography

 

Lucie Khemtemourian is a CNRS researcher at the “Laboratoire des Biomolecules”, Paris. After completing a PhD in biophysics on peptides structure and peptide-membrane interactions at the University of Bordeaux, she worked on peptides folding as a post-doc at the “Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques”, Paris, and on peptides misfolding at Utrecht University. Since 2009, she is using biophysical and biological techniques to determine amyloid peptide structure, interactions and toxicity.

 

 

 

 

 

CBMN Accueil Intro Actualités Séminaires Publications Plateformes Offres d'emploi
Départements Administration Biologie et Biotechnologie Chimie Biomimétique et Thérapeutique Chimie Biophysique
Un problème sur le site? Contactez notre webmaster : webmaster@cbmn.u-bordeaux.fr
Services Direction Directoire Scientifique Administration Communication Hygiène & Sécurité WEB Editorial Committee Animation Scientifique Conseil d'Unité Plateau Technique
EXT INDIA UMT FOLIES UREKA IPEP master Master AC2QMAPS Réseau RMN Aquitain GEM LIA France-Japan
Équipes Patricia DULOR Anthony BOUTER Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Yann FERRAND Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Marc BONNEU
informations Mentions légales Plan d'accès Réalisation : Little Big Studio
Dernière mise à jour : 10/08/2018

CNRS Université de Bordeaux Institut Polytechnique de Bordeaux

CBMN Allée de Geoffroy St Hilaire Bât B14
33600 Pessac
Tél. : +33 (0)5 40 00 68 00
Fax : +33 (0)5 40 00 22 00
Mail : contact@cbmn.u-bordeaux.fr