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Marc-André SELOSSE, 23 septembre 2... Christophe Bucher, Thursday July 18... Mélanie Berbon, 11 juillet 2019, 1... Hendrik W. Van Veen, July 11th, 201... Sébastien Ulrich, July 4th, 2019 ... Frédéric Brossard, 1st of July, 1... Prof. Solange Landreville, 19th of ... Prof. Hiroshi Yabu, 27th of May, 11... Amitabha Chattopadhyay, 22 May, 11 ... Prof. Hiroaki Suga, 10/05/2017, 11 ... INTERNAL CBMN SEMINAR: PHD student ... Jean Duhamel, 4 april 2019, 11am, I... Internal CBMN seminar 7 March 2019... Sandrine VIllette, 7 february 2019,... Internal CBMN Seminar : newcomers ... Internal CBMN Seminar: A. Simon, 6 ... Marisela Velez, 28 november 2018, 2... Marc Bramkamp, 16 november 2018, 2p... Kazushi Kinbara, 12 november 2018, ... Internal CBMN Seminar: J. Lang, 8 N... Internal CBMN Seminars: A. Baudin, ... Plateforme production de protéine... Patrick Trouillas, 21 June 2018, 2p... Lucie Khemtemourian, 21 June 2018, ... Jonathan Faherty, 7th June, 11 AM, ... Yann Fichou, 3 May 2018, 2pm, IECB Internal CBMN seminars: A. Ciaccafa... Alain Roussel, 29/03/2018, 4 pm, EN... Simon Poly, 22 march 2018, 2pm, ENS... J.Crassous, M. Sallé & A. Martinez... O.Reinaud & V. Artero, 7/12/2017, 1... R. Dos santos Morais, 30/11/2017, 4... Christian Griesinger, November 24th... Takahiro Muraoka, 16/11/2017, 11am,... Vladimir Torbeev, 9/11/2017, 2pm, E... M. D. Smith & T.Constantieux, 3/11/... James Nowick, 15 september 2017, 11... Emmanuelle Thinon, 28 June 2017, 11... Caroline Tokarski, 15 June 2017, 4p... Christian Salesse, 8 June 2017, 4pm... Patrice Rey, 01 June 2017, 2h30 pm,... Christina Sizun, 18 May 2017, 4 pm,... Marisela Velez, 5 May 2017, 11am, I... Iqbal Choudhary, 27 April 2017, 4 p... Vincent Aucagne, 21 April 2017, 11 ... Sophie Zinn-Justin, 14 April 2017, ... Cécile Feuillie, 16 February 2017,... Félix M. Goñi, 8 december 2016, 4... Félix M. Goñi, 17 november 2016, ... Carl Creutz, 20 october 2016, 4 pm,... Diego Romero, 30 september 2016, 11... A. Ciaccafava, 8 september 2016, 14... A. Ramamoorthy, 16 June 2016, 16h,... Alexandre de Brevern, 2 june 2016, ... Isabelle Landrieu, 26 May, 16h, ENS... Frances Sepavoric, 12 May, 16h, ENS... Thomas Pradeu, 7 April 2016, 9h, EN... Françoise Argoul, 3 march 2016, 1... Corinne Loutelier-Bourhis, 16/12/20... Aristotelis XENAKIS, 3 december 201... Fabian Kiessling, 26 november 2015,... Michaël Molinari, 20 november 2015... Dipankar Das Sarma, 28 October 2015... Olivier Donard, 22 october 2015, 16... E. Morvan & A.Grelard, 17/12/2015, ... Christophe Cullin, 10 september 201... Brigitte Lindet, 18 June 2015, 16h,... Marion Decossas, 4 June 2015, 16h, ... Pascale Schellenberger, 21 Mai 2015... F. Leal-Calderon, 7 May 2015, 16h, ... Ibrahim Abdulhalim, 9 April 2015, 1... Manon Carré, 26 March 2015, 14h, ... C. Bure & JM Schmitter, 19 March 20... T. Ogata & H. Ihara, 17 March 2015,... Banafshe Larijani, 12 March 2015, 1...
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Patricia DULOR Anthony BOUTER Olivier LAMBERT Jochen LANG Pascale SUBRA-PATERNAULT Maria URDACI Marie-Christine DURRIEU Xavier SANTARELLI Gilles GUICHARD Yann FERRAND Isabelle BESTEL Juan ELEZGARAY Antoine LOQUET Sophie LECOMTE Reiko ODA Caroline TOKARSKI

Prof. Hiroaki Suga, 10/05/2017, 11 am, IECB

The seminar will take place the 10th of May 2019, at 11am in the IECB amphitheatre, 2 rue Robert Escarpit Pessac.

Contact: Gilles Guichard, g.guichard@cbmn.u-bordeaux.fr

 

Revolutionizing the discovery processes of de novo bioactive peptides and biologics

 

Prof. Hiroaki Suga

Department of Chemistry, University of Tokyo, Japan

hsuga@chem.s.u-tokyo.ac.jp

URL : http://www.chem.s.u-tokyo.ac.jp/users/bioorg/English/

 

Abstract :

Macrocyclic peptides possess a number of pharmacological characteristics distinct from other well-established therapeutic molecular classes, resulting in a versatile drug modality with a unique profile of advantages. Macrocyclic peptides are accessible by not only chemical synthesis but also ribosomal synthesis. Particularly, recent inventions of the genetic code reprogramming integrated with an in vitro display format, referred to as RaPID (Random non-standard Peptides Integrated Discovery) system, have enabled us to screen mass libraries (>1 trillion members) of non-standard peptides containing multiple non-proteinogenic amino acids, giving unique properties of peptides distinct from conventional peptides, e.g. greater proteolytic stability, higher affinity (low nM to sub nM dissociation constants), and superior pharmacokinetics. The field is rapidly growing evidenced by increasing interests from industrial sectors, including small start-ups as well as mega-pharmas, toward drug development efforts on macrocyclic peptides, which has led to several de novo discovered peptides entering pre-clinical and clinical trials. This lecture discusses the aforementioned RaPID system and several showcases of therapeutic potentials of macrocyclic peptides generated by the Suga’s laboratory and collaborations with other laboratories.

 

A. Kawamura, M. Münzel, T. Kojima, C. Yapp, B. Bhushan, Y. Goto, A. Tumber, T. Katoh, O.N. King, T. Passioura, L.J. Walport, S.B. Hatch, S. Madden, S. Müller, P.E. Brennan, R. Chowdhury, R.J. Hopkinson, H. Suga*, C.J. Schofield “Highly selective inhibition of histone demethylases by de novo macrocyclic peptides” Nature Communications, (2017) Apr. 6, 14773.

H. Yu, P. Dranchak, Z. Li, R. MacArthur, M.S. Munson, N. Mehzabeen, N.J. Baird, K.P. Battalie, D. Ross, S. Lovell, C.K. Carlow, H. Suga*, J. Inglese,. “Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases” Nature Communications, (2017) Apr. 3, 14932.

S.A. Jongkeess, S. Caner, C. Tysoe, G.D. Brayer, S.G. Withers, H. Suga* “Rapid discovery of potent and selective glycosidase-inhibiting de novo peptides” Cell Chemical Biology, (2017) 24, 381-390.

T. Katoh; I. Wohlgemuth; M. Nagano; M.V. Rodnina; H. Suga "Essential structural elements in tRNA(Pro) for EF-P-mediated alleviation of translation stalling." Nature communications, 7, 11657 (2016)

Y. Iwane; A. Hitomi; H. Murakami; T. Katoh; Y. Goto; H. Suga*, “Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes”, Nature Chemistry, 8, 317–325 (2016)

K. Ito; K. Sakai; Y. Suzuki; N. Ozawa; T. Hatta; T. Natsume; K. Matsumoto; H. Suga "Artificial human Met agonists based on macrocycle scaffolds" Nature Communications, 6, 6373 (2015)

 

Biography :

Hiroaki Suga is a Professor of the Department of Chemistry, Graduate School of Science in the University of Tokyo. He was born in Okayama City, Japan in 1963. He received his Bachelor of Engineering (1986) and Master of Engineering (1989) from Okayama University, and Ph. D. in Chemistry (1994) from the Massachusetts Institute of Technology. After three years of post-doctoral work in Massachusetts General Hospital, he was appointed as a tenure-track Assistant Professor in the Department of Chemistry in the State University of New York (SUNY) at Buffalo (1997) and promoted to the tenured Associate Professor (2002). In 2003, he moved to the Research Center for Advanced Science and Technology in the University of Tokyo as an Associate Professor, and soon after he was promoted to Full Professor. In 2010, he changed his affiliation to the Department of Chemistry, Graduate School of Science. His research interests are in the field of bioorganic chemistry, chemical biology and biotechnology related to RNA, translation, peptides and pseudo-natural products. He is the recipient of Akabori Memorial Award 2014 of Japanese Peptide Society, Max-Bergmann Gold Medal 2016, Nagoya Medal Silver 2017, and Vincent du Vigneaud Award 2019. He is also a founder of PeptiDream Inc. Tokyo, a publicly traded company in the Tokyo First Stock Exchange Market, which has many partnerships with pharmaceutical companies in worldwide.

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