Spectrométrie de Masse des Macromolécules Biologiques

Dir. : Jean-Marie SCHMITTER

    Le groupe s'intéresse à plusieurs thèmes: i) l'agrégation de protéines : prion HET-s, lithostatine, ii) l'échange isotopique H/D sur protéines membranaires, iii) l'analyse protéomique de protéines membranaires, iv) la protéomique et la peptidomique clinique, v) les souches de Bacillus à activités antimicrobiennes et les vi) interactions tannins-protéines.

    Le groupe développe aussi la spectrométrie de masse Maldi-Tof, Esi-Tof, Q-Tof, MS/MS et l'analyse protéomique.

 

Equipe :

Katell BATHANY Corinne BURE Stéphane CHAIGNEPAIN
Céline CHOLLET Boutayna FRIH Ecaterina LOZAN
Latifa MALKI Luc NEGRONI

Publications :

1 - ?Pinsolle, A.; Roy, P.; Bure, C.; Thienpont, A.; Cansell, M.
Enzymatic synthesis of phosphatidylserine using bile salt mixed micelles. .
Colloids and Surfaces.B: Biointerfaces., 2013, , .
2 - Ayciriex, S.; Le Guedard, M.; Camougrand, N.; Velours, G.; Schoene, M.; Leon, S.; Wattelet-Boyer, V.; Dupuy, J. W.; Shevchenko, A.; Schmitter, J. M.; Lessire, R.; Bessoule, J. J.; Testet, E.
YPR139c/LOA1 encodes a novel lysophosphatidic acid acyltransferase associated with lipid droplets and involved in TAG homeostasis.
Molecular Biology of the Cell, 2012, 23, 233-246.
-Abstract-
3 - Botta, A.; Delteil, F.; Mettouchi, A.; Viera, A.; Estrach, S.; Negroni, L.; Stefani, C.; Lemichez, E.; Meneguzzi, G.; Laurent, G. P.
Confluence switch signalling regulates ECM composition and plasmin proteolytic cascade in keratinocytes.
J. Cell. Sci., 2012, May 28, .
4 - Negroni, L.; Claverol, S.; Rosenbaum, J.; Chevet, E.; Bonneu, M.; Schmitter, J. M.
Comparison of IMAC and MOAC for phosphopeptide enrichment by column chromatography.
Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2012, 891, 109-112.
-Abstract-
5 - Azema, L.; Bathany, K.; Rayner, B.
2 '-O-Appended Polyamines that Increase Triple-Helix-Forming Oligonucleotide Affinity are Selected by Dynamic Combinatorial Chemistry.
Chembiochem, 2011, 11, 2513-2516.
6 - Bure, C.; Cacas, J. L.; Wang, F.; Gaudin, K.; Domergue, F.; Mongrand, S.; Schmitter, J. M.
Fast screening of highly glycosylated plant sphingolipids by tandem mass spectrometry.
Rapid Communications in Mass Spectrometry, 2011, 25, 3131-3145.
-Abstract-
7 - Commandeur, C.; Commandeur, M.; Bathany, K.; Kauffmann, B.; Edmunds, A. J. F.; Maienfisch, P.; Ghosez, L.
Study of the oxidation of 3-hydroxypyrroloindoles to pyrrolobenzoxazine alkaloids.
Tetrahedron, 2011, 67, 9899-9908.
-Abstract-
8 - Xuereb, F.; Chaignepain, S.; Breilh, D.; Godde, F.; Saux, M. C.; Lenz, C.; Glueckmann, M.; Schmitter, J. M.
Quantitative analysis of erythropoietin in human plasma by tandem mass spectrometry.
Analytical and Bioanalytical Chemistry, 2011, 400, 2073-2084.
-Abstract-
9 - Baco, E.; Vellutini, L.; Pillot, J. P.; Felpin, F. X.; Schmitter, J. M.; Bennetau, B.; Degueil, M.
Synthesis of Novel Haptens and Conjugates for Antibody Production against Kainoid Family.
Synlett, 2010, , 1943-1946.
-Abstract-
10 - Gargouri, M.; Chaudiere, J.; Manigand, C.; Mauge, C.; Bathany, K.; Schmitter, J. M.; Gallois, B.
The epimerase activity of anthocyanidin reductase from Vitis vinifera and its regiospecific hydride transfers.
Biological Chemistry, 2010, 391, 219-227.
-Abstract-
11 - Hocquellet, A.; Odaert, B.; Cabanne, C.; Noubhani, A.; Dieryck, W.; Joucla, G.; Le Senechal, C.; Milenkov, M.; Chaignepain, S.; Schmitter, J. M.; Claverol, S.; Santarelli, X.; Dufourc, E. J.; Bonneu, M.; Garbay, B.; Costaglioli, P.
Structure-activity relationship of human liver-expressed antimicrobial peptide 2.
Peptides, 2010, 31, 58-66.
-Abstract-
12 - Mauge, C.; Granier, T.; Langlois d'Estaintot, B.; Gargouri, M.; Manigand, C.; Schmitter, J. M.; Chaudiere, J.; Gallois, B.
Crystal Structure and Catalytic Mechanism of Leucoanthocyanidin Reductase from Vitis vinifera.
Journal of Molecular Biology, 2010, 397, 1079-1091.
-Abstract-
13 - Sanchez, B.; Saad, N.; Schmitter, J. M.; Bressollier, P.; Urdaci, M. C.
Adhesive Properties, Extracellular Protein Production, and Metabolism in the Lactobacillus rhamnosus GG Strain when Grown in the Presence of Mucin.
Journal of Microbiology and Biotechnology, 2010, 20, 978-984.
-Abstract-
14 - Shinkaruk, S.; Lamothe, V.; Schmitter, J. M.; Manach, C.; Morand, C.; Berard, A.; Bennetau, B.; Bennetau-Pelissero, C.
Development and validation of two new sensitive ELISAs for Hesperetin and Naringenin in biological fluids.
Food Chemistry, 2010, 118, 472-481.
-Abstract-
CNRS-BordeauxI-IPB

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