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How AI is revolutionizing histological analysis and cellular imaging?

Mardi 30 Avril, à 11h, IECB Auditorium

Dr Victor Racine


Founder & CEO of QuantaCell SAS
Hôpital Saint Eloi, IRMB, Montpellier


Thursday, April 30, 2026 at 11:00 AM
IECB auditorium, 2 rue Robert Escarpit, 33600 Pessac


Host: BioFAP Department of CBMN (M Raoux, A Bouter, O Lambert)


Summary:

Bio-imaging is rapidly expanding, from cell culture systems (2D/3D, organoids) to digital
histology, yet one major bottleneck remains: limited annotated data and time-consuming
analysis.
In this talk, Victor Racine will explore how foundation models are reshaping the field by
enabling powerful image analysis across scales:

Automated analysis in cell culture and high-content screening;

Robust feature extraction and tumor detection in histology;

Strong performance, even with limited data

Selected publications related to this presentation:

Ong et al. (2025) Digitalized organoids: integrated pipeline for high-speed 3D analysis of organoid
structures using multilevel segmentation and cellular topology. Nat Methods 22:1343–1354.
Domblides et al. (2024) Human NLRC4 expression promotes cancer survival and associates with type I
interferon signaling and immune infiltration. J Clin Invest 134:e166085.
Charrasse et al. (2023) Quantitative assessment of mitochondrial morphology relevant for studies on
cellular health and environmental toxicity. Comput Struct Biotechnol J. 21:5609-561.
Beghin et al. (2022) Automated high-speed 3D imaging of organoid cultures with multi-scale
phenotypic quantification. Nat Methods 19:881–892.
Blanc et al. (2020) Artificial intelligence solution to classify pulmonary nodules on CT. Diagn Interv
Imaging 101:803–810.
Frye et al. (2021) Mitochondrial morphology is associated with respiratory chain uncoupling in autism
spectrum disorder. Transl Psychiatry 11:527

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  1. Gounou C., Rouyer L., Siegfried G., Harté E., Bouvet F., d’Agata L., Darbo E. , Lefeuvre M., Derieppe M.A., Bouton L., Mélane M., Chapeau D., Martineau J., Prouzet-Mauleon V., Tan S., Souleyreau W., Saltel F., Argoul F., Khatib A.M., Brisson A.R., Iggo R., Bouter A. (2024) Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis. Cell Mol Life Sci. 81(1):7.
  2. Gounou C., Bouvet F., Liet B., Prouzet-Mauléon V., d’Agata L., Harté E., Argoul F., Siegfried G., Iggo R., Khatib A..M., Bouter A. (2023) Annexin-A5 and annexin-A6 silencing prevents metastasis of breast cancer cells in zebrafish. Biol Cell. 115 (6):e202200110.
  3. Bouvet F., Ros M., Bonedeau E., Croissant C., Frelin L., Saltel F., Moreau V., Bouter A. (2020) Defective membrane repair machinery impairs survival of invasive cancer cells. Scientific Reports, 10, 1-16.

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  1. Ducat A., Couderc B., Bouter A., Biquard L., Aouache R., Passet B., Doridot L., Cohen M.B., Ribaux P., Apicella C., Gaillard I., Palfray S., Chen Y., Vargas A., Julé A., Frelin L., Cocquet J., Ruano C., Jacques S., Busato F., Tost J., Méhats C., Laissue P., Vilotte J.L., Miralles F., Vaiman D. (2020) Molecular mechanisms of trophoblast dysfunction mediated by imbalance between STOX1 isoforms. iSciences. 23 (5):101086. doi: 10.1016/j.isci.2020.101086.
  2. Bouter A., Carmeille R., Gounou C., Bouvet F., Degrelle S.A., Evain-Brion D., Brisson A.R. (2015) Review: Annexin-A5 and cell membrane repair. Placenta, 36 (1), S43-S49.
  3. Carmeille R., Degrelle S.A., Plawinski L., Bouvet F., Gounou C., Evain-Brion D., Brisson A.R., Bouter A. (2015) Annexin-A5 promotes membrane resealing in human trophoblasts. Biochim. Biophys. Acta., 1853, 2033-2044.
  4. Bouter A., Gounou C., Bérat R., Tan S. Gallois B., Granier T., Langlois d’Estaintot B., Pöschl E., Brachvogel B. and Brisson A.R. (2011) Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair. Nat. Commun. 2:270 doi: 10.1038/ncomms1270.

Bibliographie

  1. d’Agata L., Rassinoux P., Gounou C., Bouvet F., Bouragba D., Mamchaoui K. and Bouter A. (2024) A novel assay reveals the early setting-up of membrane repair machinery in human skeletal muscle cells. J Cell Biochem Sept 30:e30662. doi: 10.1002/jcb.30662.
  2. Croissant C., Gounou C., Bouvet F., Tan S. and Bouter A. (2022) Trafficking of Annexins during Membrane Repair in Human Skeletal Muscle Cells. Membranes, 12(2), 153.
  3. Croissant C., Carmeille R., Brevart C. and Bouter A. (2021) Annexins and membrane repair dysfunctions in muscular dystrophies. Int. J. Mol. Sci., 22, 5276.
  4. Croissant C., Gounou C., Bouvet F., Tan S. and Bouter A. (2020) Annexin-A6 in membrane repair of human skeletal muscle cell: a role in the cap subdomain. Cells, 9, 1742. doi:10.3390/cells9071742.
  5. Croissant C., Bouvet F., Tan S. and Bouter A. (2018) Imaging membrane repair in single cells using correlative light and electron microscopy. Curr Protoc Cell Biol, e55. doi: 10.1002/cpcb.55.
  6. Carmeille R., Croissant C., Bouvet F. and Bouter A. (2017) Membrane repair assay for human skeletal muscle cells. Methods Mol Biol., 1668, 195-207.
  7. Carmeille R., Bouvet F., Tan S., Croissant C., Gounou C., Mamchaoui K., Mouly V., Brisson A.R., Bouter A. (2016) Membrane repair of human skeletal muscle cells requires Annexin-A5. Biochim. Biophys. Acta., 1863, 2267-2279.
  8. Bouter A., Gounou C., Bérat R., Tan S. Gallois B., Granier T., Langlois d’Estaintot B., Pöschl E., Brachvogel B. and Brisson A.R. (2011) Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair. Nat. Commun. 2:270 doi: 10.1038/ncomms1270.

MSB

Biophysique multi-échelle

5 groupes de recherche

NMFAB

Applications de biomolécules pour le médical, la cosmétique, la nutraceutique, et l'agroalimentaire.

3 groupes de recherche

CBSC

Biologie chimique et Chimie supramoléculaire

5 groupes de recherche

Nos enseignants-chercheurs participe à la formation des élèves ingénieurs de Bordeaux INP (ENSMAC, ENSTBB…) et de l’université de Bordeaux.